CD53 and TMEM60

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD53	TMEM60
Description		CD53 molecule	transmembrane protein 60
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell-cell Junction Membrane Specific Granule Membrane Synapse Extracellular Exosome Anchoring Junction Tertiary Granule Membrane	Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein-membrane Adaptor Activity	Protein Binding
	Biological Process	Signal Transduction Receptor Clustering T Cell Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)	Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 30604766 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199)
Interacting Genes		80 interacting genes: AIG1 APOD ARL13B ASGR2 ATP6V0C BCL2L13 BIK BTN2A2 C1QL4 CD2 CD302 CD37 CD4 CD9 CLCN7 CLDN19 CLDN7 CLEC7A CNIH1 CNIH2 COL4A5 CREB3L1 CTXN3 CXCL16 CYBC1 ECE2 EFNA5 EMP1 ERG28 FAM209A GET1 GGT1 GIMAP5 GJA8 GPR108 GPR152 GPX8 IFITM3 IGFBP5 IL2 IL4 KIR3DL3 LAT LHFPL5 LPAR3 LSMEM1 MAL MS4A3 MUC1 NKG7 PLN PLP2 PMP22 PSCA RPRM SAR1A SERTM1 SLC35A1 SLC7A14 SMAGP SMIM3 SNORC ST6GAL2 STRIT1 STX2 TMEM128 TMEM140 TMEM218 TMEM229B TMEM237 TMEM60 TMEM86B TMEM97 TRAM1L1 TRARG1 TSPO2 UBIAD1 UPK1B VAMP5 VSTM1	91 interacting genes: AMIGO1 ANKS6 APOL2 AQP2 AQP6 ARL13B ASGR2 BEST2 BIK BSND CD300A CD53 CD74 CLDN7 CNR2 CPLX4 CYB5R3 EBP EDA ERGIC3 EVI2B FAM209A FFAR2 FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPR42 GPX8 HERPUD2 HIBADH HSD17B13 IFNGR2 KCNK5 KIAA2013 LEUTX LHFPL5 LMNA LRRC3B LRRC59 MFF MGST3 MMD MMGT1 PAGE1 PGRMC2 PI16 REEP2 REEP4 RETREG3 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC13A4 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SLC30A4 SLC35E3 SLC35H1 SLC38A1 SLC39A2 SLC4A1 SLC7A8 SPAG4 SPNS3 SSMEM1 STOM STX1A SYT1 THAP4 TLCD4 TMCO5A TMED9 TMEM139 TMEM14B TMEM203 TMEM237 TMEM45B TMEM52B TMEM86B TMEM9 TMPPE TMPRSS2 TTYH1 VMA21
Entrez ID		963	85025
HPRD ID		01054	12923
Ensembl ID		ENSG00000143119	ENSG00000135211
Uniprot IDs		B4DQB5 P19397	Q9H2L4
PDB IDs		6WVG
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Membrane Raft Distribution Membrane Raft Localization Protein Binding Bleb Assembly Membrane Raft Polarization T Cell Activation Endomembrane System Membrane Raft Organization Endoplasmic Reticulum Membrane Defense Response To Protozoan Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Membrane Transmembrane Transport Protein Binding Monoatomic Ion Transport Plasma Membrane Basolateral Plasma Membrane Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Endoplasmic Reticulum Membrane Transport Vesicle Membrane Monoatomic Ion Transmembrane Transport Endoplasmic Reticulum Antiporter Activity Metal Ion Transport Organic Anion Transport Inorganic Cation Transmembrane Transport Inorganic Anion Transmembrane Transport Cytoplasmic Vesicle Zinc Export Across Plasma Membrane Inorganic Anion Transport Monoatomic Cation Transmembrane Transport Connexin Complex Chloride Transmembrane Transport Gap Junction Channel Activity Regulation Of PH Symporter Activity Neurotransmitter Transport Zinc Ion Import Into Lysosome Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Carbon Dioxide Transmembrane Transporter Activity Chloride Transport Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Zinc Ion Transmembrane Transporter Activity Lysosomal Lumen Acidification Gap Junction Zinc Ion Transmembrane Transport Transmembrane Transporter Activity Zinc Ion Transport Gap Junction-mediated Intercellular Transport Sodium Ion Transport Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Amino Acid Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Assembly
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