AIFM1 and TSC22D4

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		AIFM1	TSC22D4
Gene Name		apoptosis-inducing factor, mitochondrion-associated, 1	TSC22 domain family, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Electron Carrier Activity NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Differentiation Chromosome Condensation Mitochondrial Respiratory Chain Complex I Assembly Positive Regulation Of Apoptotic Process Cell Redox Homeostasis Neuron Apoptotic Process Oxidation-reduction Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic DNA Fragmentation	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs		Flavin-Adenine Dinucleotide
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP3 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP	53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		9131	81628
HPRD ID		02161	18231
Ensembl ID		ENSG00000156709	ENSG00000166925
Uniprot IDs		O95831	A8MWR6 Q9Y3Q8
PDB IDs		1M6I 4FDC 4LII
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cellular Heat Acclimation Negative Regulation Of Growth Regulation Of Metabolic Process Negative Regulation Of Inclusion Body Assembly Gene Expression Cellular Response To Stress Response To Unfolded Protein Response To Oxidative Stress Regulation Of Inclusion Body Assembly Aromatic Compound Catabolic Process Protein Refolding Positive Regulation Of Erythrocyte Differentiation MRNA Catabolic Process RNA Catabolic Process Response To Abiotic Stimulus Intrinsic Apoptotic Signaling Pathway Hippo Signaling Regulation Of Cellular Response To Heat Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Regulation Of Growth Regulation Of Erythrocyte Differentiation Viral Entry Into Host Cell Entry Into Host Cell Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Death Cellular Response To Heat Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process Negative Regulation Of Developmental Growth Negative Regulation Of Cell Death Protein Stabilization Programmed Cell Death Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Mitotic Recombination Cell Death Death Negative Regulation Of Protein Ubiquitination	Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		agilent antiproliferative biologically cables2 ccnk cdc25b cdca3 cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 hspa9 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Difference) ?		agilent antiproliferative biologically cables2 ccnk cdc25b cdca3 cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 hspa9 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Intersection) ?