AIFM1 and EIF3G

Number of citations of the paper that reports this interaction (PMID 17094969)
4

Data Source:
HPRD (in vitro, two hybrid)

		AIFM1	EIF3G
Gene Name		apoptosis-inducing factor, mitochondrion-associated, 1	eukaryotic translation initiation factor 3, subunit G
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding Electron Carrier Activity NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Differentiation Chromosome Condensation Mitochondrial Respiratory Chain Complex I Assembly Positive Regulation Of Apoptotic Process Cell Redox Homeostasis Neuron Apoptotic Process Oxidation-reduction Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic DNA Fragmentation	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways			Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs		Flavin-Adenine Dinucleotide
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP3 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP	22 interactors: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 MPHOSPH6 MPP6 PIN1 PKN2 POT1 SMN1 SNCA TK1
Entrez ID		9131	8666
HPRD ID		02161	04886
Ensembl ID		ENSG00000156709	ENSG00000130811
Uniprot IDs		O95831	O75821
PDB IDs		1M6I 4FDC 4LII	2CQ0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cellular Heat Acclimation Negative Regulation Of Growth Regulation Of Metabolic Process Negative Regulation Of Inclusion Body Assembly Gene Expression Cellular Response To Stress Response To Unfolded Protein Response To Oxidative Stress Regulation Of Inclusion Body Assembly Aromatic Compound Catabolic Process Protein Refolding Positive Regulation Of Erythrocyte Differentiation MRNA Catabolic Process RNA Catabolic Process Response To Abiotic Stimulus Intrinsic Apoptotic Signaling Pathway Hippo Signaling Regulation Of Cellular Response To Heat Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Regulation Of Growth Regulation Of Erythrocyte Differentiation Viral Entry Into Host Cell Entry Into Host Cell Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Death Cellular Response To Heat Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process Negative Regulation Of Developmental Growth Negative Regulation Of Cell Death Protein Stabilization Programmed Cell Death Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Mitotic Recombination Cell Death Death Negative Regulation Of Protein Ubiquitination	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Ribonucleoprotein Complex Biogenesis Cellular Component Assembly Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Protein Metabolic Process Formation Of Cytoplasmic Translation Initiation Complex Translation Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Positive Regulation Of Telomerase Activity Cytoplasmic Translational Initiation Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Cytoplasmic Translation Negative Regulation Of Chromosome Organization Regulation Of Binding Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Maturation Of 5.8S RRNA Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Regulation Of Metabolic Process Response To Copper Ion Positive Regulation Of Catalytic Activity Gene Expression Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Ribosome Biogenesis Protein Metabolic Process Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation
Tagcloud ?		agilent antiproliferative biologically cables2 ccnk cdc25b cdca3 cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 hspa9 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2	bimolecular c2hc complementation defense eifs enhancing eukaryotic finger fragment hybrid impair interfere machinery motif nia papaya preinitiation pro protoplasts prsv residues ringspot sos translation translational validated yeast zinc
Tagcloud (Difference) ?		agilent antiproliferative biologically cables2 ccnk cdc25b cdca3 cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 hspa9 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2	bimolecular c2hc complementation defense eifs enhancing eukaryotic finger fragment hybrid impair interfere machinery motif nia papaya preinitiation pro protoplasts prsv residues ringspot sos translation translational validated yeast zinc
Tagcloud (Intersection) ?