AIFM1 and WWC1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		AIFM1	WWC1
Description		apoptosis inducing factor mitochondria associated 1	WW and C2 domain containing 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding NADH Dehydrogenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding Poly-ADP-D-ribose Binding	Transcription Coactivator Activity Protein Binding Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	Response To Ischemia Apoptotic Process Response To Toxic Substance Neuron Differentiation Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Protein Import Into Mitochondrial Intermembrane Space Positive Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Nitric Oxide Mitochondrial Disulfide Relay System Response To L-glutamate Cellular Response To Aldosterone	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Migration Establishment Of Cell Polarity Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Negative Regulation Of Organ Growth
Pathways			Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription
Drugs		Flavin adenine dinucleotide MCC
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Bipolar disorder ( 31043756)	Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)
Interacting Genes		11 interacting genes: CASP3 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP	16 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK UBC WWC2 WWC3
Entrez ID		9131	23286
HPRD ID		02161	10033
Ensembl ID		ENSG00000156709	ENSG00000113645
Uniprot IDs		E9PMA0 O95831	Q8IX03
PDB IDs		1M6I 4BUR 4BV6 4FDC 4LII 5FMH 5FS6 5FS7 5FS8 5FS9 5KVH 5KVI 8D3E 8D3G 8D3H 8D3I 8D3J 8D3K 8D3N 8D3O 8VGY	2Z0U 6FB4 6FD0 6FJC 6FJD
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Metabolic Process Negative Regulation Of Growth Positive Regulation Of Microtubule Nucleation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Inclusion Body Perinuclear Region Of Cytoplasm Regulation Of Microtubule Nucleation Response To Oxidative Stress MRNA Catabolic Process Regulation Of Inclusion Body Assembly Regulation Of Mitotic Spindle Assembly Response To Lipid Execution Phase Of Apoptosis Enzyme Binding Protein Refolding Positive Regulation Of Defense Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand ATP-dependent Protein Folding Chaperone Positive Regulation Of Microtubule Polymerization Regulation Of Spindle Assembly Regulation Of Protein Ubiquitination RNA Catabolic Process Cellular Response To Stress Regulation Of Mitotic Spindle Organization Response To Steroid Hormone Macromolecule Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Erythrocyte Differentiation Regulation Of Post-translational Protein Modification Cellular Response To Heat Regulation Of Growth Intracellular Signal Transduction Response To Hormone Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment	Negative Regulation Of Autophagosome Assembly
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