PGS1

Description		phosphatidylglycerophosphate synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Catalytic Activity Calcium Ion Binding ATP Binding CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Transferase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Phospholipid Biosynthetic Process Cardiolipin Biosynthetic Process Diacylglycerol Metabolic Process
Pathways		Synthesis of PG
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) HDL cholesterol ( 24097068 25961943 30275531 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Systemic lupus erythematosus ( 33272962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)
Interacting Genes		2 interacting genes: GABARAP PDLIM1
Entrez ID		9489
HPRD ID		17841
Ensembl ID		ENSG00000087157
Uniprot IDs		Q32NB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Alpha-actinin Binding Establishment Or Maintenance Of Actin Cytoskeleton Polarity Maintenance Of Cell Polarity Cadherin Binding Involved In Cell-cell Adhesion Actin Cytoskeleton Fibroblast Migration Regulation Of Protein K48-linked Ubiquitination Phosphatidylethanolamine Binding GABA Receptor Binding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Smooth Endoplasmic Reticulum Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Cellular Response To Nitrogen Starvation Filamentous Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Protein Polyubiquitination Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Rac Protein Signal Transduction Microtubule Associated Complex Beta-tubulin Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Autophagosome Maturation Sperm Midpiece Autophagosome Membrane Mitophagy Cytoskeleton Actin Filament Bundle Assembly Actin Filament Bundle Organization Autophagy Of Mitochondrion
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