MTMR6 and AMOTL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MTMR6	AMOTL2
Description		myotubularin related protein 6	angiomotin like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm	Podosome Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Junction Cytoplasmic Vesicle Cell Projection Recycling Endosome Anchoring Junction
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity	Protein Binding Actin Filament Binding
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Protein Localization
Pathways		Synthesis of PIPs at the plasma membrane	Signaling by Hippo
Drugs
Diseases
GWAS		Metabolite levels ( 31628463) Triglyceride levels ( 32203549)	Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		14 interacting genes: AATK ALKBH4 AMOTL2 ERBB3 ERBB4 LMTK2 MTMR9 MTNR1B MTUS2 NMI PTK7 RARG ROR2 TRIM27	92 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DSCAM DTNB DYNLL1 DZIP1L EIF4E2 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTCL2 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT
Entrez ID		9107	51421
HPRD ID		11946	16485
Ensembl ID		ENSG00000139505	ENSG00000114019
Uniprot IDs		A0A9L9PXJ0 Q9Y217	Q9Y2J4
PDB IDs		2YF0
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Wnt Signaling Pathway Kinase Activity ERBB2 Signaling Pathway Establishment Of Planar Polarity Regulation Of Type I Interferon Production Transferase Activity ATP Binding Receptor Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Activity Establishment Of Planar Polarity Involved In Nephron Morphogenesis Protein Sumoylation Negative Regulation Of Type I Interferon Production DNA N6-methyladenine Demethylase Activity Positive Regulation Of Cardiac Muscle Tissue Development Heart Development ERBB3:ERBB2 Complex Basal Plasma Membrane Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Morphogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Coreceptor Activity Cellular Response To Retinoic Acid Protein Polyubiquitination Regulation Of Interferon-beta Production Myosin VI Binding Cleavage Furrow Ingression Wound Healing ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication ErbB-3 Class Receptor Binding Neuron Apoptotic Process Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Cardiac Muscle Tissue Regeneration Developmental Growth Olfactory Bulb Interneuron Differentiation ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Activity Melatonin Receptor Activity Regulation Of Neuronal Action Potential Camera-type Eye Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep	Keratin Filament Intermediate Filament Intermediate Filament Organization Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Protein Binding Identical Protein Binding Structural Constituent Of Cytoskeleton Cytoskeleton Organization Ubiquitin Protein Ligase Binding Structural Molecule Activity Nucleus Cytosol Centriolar Satellite Organelle Organization Protein Polyubiquitination Centrosome Chromosome, Centromeric Region HULC Complex PML Body Supramolecular Fiber Organization Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Primary Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Cell Cycle
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