MTMR6 and ALKBH4

Number of citations of the paper that reports this interaction (PubMedID 23145062)
75

Data Source:
BioGRID (two hybrid)

		MTMR6	ALKBH4
Description		myotubularin related protein 6	alkB homolog 4, lysine demethylase
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Midbody Contractile Ring
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity	Actin Binding Protein Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity Protein Demethylase Activity DNA N6-methyladenine Demethylase Activity
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation	Chromatin Organization Actomyosin Structure Organization Cleavage Furrow Ingression Demethylation Positive Regulation Of Gene Expression, Epigenetic
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Metabolite levels ( 31628463) Triglyceride levels ( 32203549)	Morning person ( 30696823)
Interacting Genes		14 interacting genes: AATK ALKBH4 AMOTL2 ERBB3 ERBB4 LMTK2 MTMR9 MTNR1B MTUS2 NMI PTK7 RARG ROR2 TRIM27	19 interacting genes: BPIFA1 DTX2 EIF3C EP300 FAM168A GORASP2 HSF4 LCN2 MLLT1 MLLT3 MTMR6 NIF3L1 PSMA6 TCF4 TES TRAF4 TXNL4B WEE2-AS1 ZFHX3
Entrez ID		9107	54784
HPRD ID		11946	07875
Ensembl ID		ENSG00000139505	ENSG00000160993
Uniprot IDs		A0A9L9PXJ0 Q9Y217	Q9NXW9
PDB IDs		2YF0
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Wnt Signaling Pathway Kinase Activity ERBB2 Signaling Pathway Establishment Of Planar Polarity Regulation Of Type I Interferon Production Transferase Activity ATP Binding Receptor Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Activity Establishment Of Planar Polarity Involved In Nephron Morphogenesis Protein Sumoylation Negative Regulation Of Type I Interferon Production DNA N6-methyladenine Demethylase Activity Positive Regulation Of Cardiac Muscle Tissue Development Heart Development ERBB3:ERBB2 Complex Basal Plasma Membrane Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Morphogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Coreceptor Activity Cellular Response To Retinoic Acid Protein Polyubiquitination Regulation Of Interferon-beta Production Myosin VI Binding Cleavage Furrow Ingression Wound Healing ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication ErbB-3 Class Receptor Binding Neuron Apoptotic Process Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Cardiac Muscle Tissue Regeneration Developmental Growth Olfactory Bulb Interneuron Differentiation ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Activity Melatonin Receptor Activity Regulation Of Neuronal Action Potential Camera-type Eye Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
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