AP5B1 and NIF3L1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		AP5B1	NIF3L1
Description		adaptor related protein complex 5 subunit beta 1	NGG1 interacting factor 3 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Late Endosome AP-type Membrane Coat Adaptor Complex AP-5 Adaptor Complex	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Endosomal Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Neuron Differentiation Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 34103634 31619474 31361310 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Atopic march ( 26542096) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Eczema ( 31361310) Glomerular filtration rate (creatinine) ( 26831199) Gout ( 33832965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Psoriasis ( 25854761) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) White matter hyperintensity volume ( 33293549)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		6 interacting genes: CALCOCO2 CFTR KCNRG MAP1LC3A NIF3L1 PDLIM7	93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		91056	60491
HPRD ID		13223	10424
Ensembl ID		ENSG00000254470	ENSG00000196290
Uniprot IDs		Q2VPB7	Q9GZT8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Autophagosome Membrane Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Macroautophagy Cellular Response To Oxygen-glucose Deprivation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Xenophagy Positive Regulation Of Autophagosome Maturation Response To Iron(II) Ion Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Cellular Response To Nitrogen Starvation Regulation Of Delayed Rectifier Potassium Channel Activity Response To Oxygen-glucose Deprivation Regulation Of Monoatomic Anion Transport Regulation Of Monoatomic Ion Transmembrane Transport Epithelial Fluid Transport Autophagy Autolysosome Golgi-associated Vesicle Membrane Phosphatidylethanolamine Binding Cellular Response To Forskolin Muscle Alpha-actinin Binding Regulation Of Autophagosome Maturation Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Response To Lead Ion	Identical Protein Binding Cytoplasm Protein Binding Cytosol Protein Complex Oligomerization Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Ethanol Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Nucleoside Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Sulfation Pyrimidine Nucleotide Metabolic Process Polyamine Catabolic Process Nucleus Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination
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