PCGF5 and DHX57

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PCGF5	DHX57
Description		polycomb group ring finger 5	DExH-box helicase 57
Image			No pdb structure
GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm Golgi Apparatus Centrosome PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding RNA Polymerase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome	Positive Regulation Of Translation
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Obesity-related traits ( 23251661)
Interacting Genes		9 interacting genes: CBX7 CBX8 DHX57 PRMT6 QKI TRAF2 TRIM8 UBE2D3 USP10	25 interacting genes: CARD10 CBX2 CEP44 EIF4ENIF1 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP9-4 NAA10 PCGF5 PLAGL2 RBMY1A1 RSPO4 ZNF473 ZNF587 ZNF837
Entrez ID		84333	90957
HPRD ID		17825	09919
Ensembl ID		ENSG00000180628	ENSG00000163214
Uniprot IDs		Q86SE9	Q6P158
PDB IDs		4S3O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PRC1 Complex Regulation Of Metabolic Process PcG Protein Complex Stress Granule Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Protein Polyubiquitination TORC2 Complex Disassembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process MRNA Stabilization Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Chromatin Organization Internal N(7)-methylguanine-containing RNA Reader Activity Histone H2AR3 Methyltransferase Activity Ubiquitin Protein Ligase Activity Regulation Of Macromolecule Metabolic Process Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stress Granule Assembly Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Histone H3R2 Methyltransferase Activity Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Histone Arginine N-methyltransferase Activity Response To Stress Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex DNA Repair	Keratin Filament Intermediate Filament
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