ZNF598 and RPS20

Number of citations of the paper that reports this interaction (PubMedID 38366554)
64

Data Source:
BioGRID (enzymatic study)

		ZNF598	RPS20
Description		zinc finger protein 598, E3 ubiquitin ligase	ribosomal protein S20
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytosolic Ribosome	Nucleoplasm Cytoplasm Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Ribosome Binding Metal Ion Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Protein Ligase Activity Protein-RNA Adaptor Activity Stalled Ribosome Sensor Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Regulation Of Translation Protein Monoubiquitination Protein Ubiquitination Ribosome Disassembly Negative Regulation Of Translational Initiation Protein K63-linked Ubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Cytoplasmic Translation Translation Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS			Height ( 18391951) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469)
Interacting Genes		8 interacting genes: CDA CXCL8 DBN1 RPS10 RPS20 RPS3 UBE2D1 UBE2D3	26 interacting genes: APP BARD1 CREBBP DUX4 ECT2 FOXP1 HMGB1 IL7R MPHOSPH6 NDRG1 NRAS PALS2 PAXIP1 PDE4B PIK3CA PLEKHO1 PTEN RABAC1 REEP6 RNF10 SP3 SUN2 TNFAIP3 TRAF6 USP40 ZNF598
Entrez ID		90850	6224
HPRD ID		11732	04728
Ensembl ID		ENSG00000167962	ENSG00000008988
Uniprot IDs		A0AAG2UWE8 Q86UK7	P60866
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Small Ribosomal Subunit Ribosome Ubiquitin Conjugating Enzyme Activity Regulation Of Cell Communication Regulation Of Signaling Response To TNF Agonist Oxidized Pyrimidine DNA Binding Negative Regulation Of BMP Signaling Pathway Translation Cellular Response To External Biotic Stimulus Cytosine Metabolic Process Cell Communication By Chemical Coupling Interleukin-8 Receptor Binding Positive Regulation Of Base-excision Repair Ribonucleoprotein Complex Cellular Response To Tumor Necrosis Factor Nucleoside Binding Regulation Of Signal Transduction Positive Regulation Of Endodeoxyribonuclease Activity Protein K48-linked Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Receptor Localization To Synapse Response To Tumor Necrosis Factor Positive Regulation Of Deoxyribonuclease Activity NF-kappaB Complex Regulation Of Base-excision Repair Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Cycloheximide Negative Regulation Of Macromolecule Biosynthetic Process UMP Salvage Pyrimidine Ribonucleotide Salvage Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Biosynthetic Process Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Positive Regulation Of Immune System Process Regulation Of Immune Response Myeloid Leukocyte Activation Leukocyte Activation Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Multicellular Organismal-level Homeostasis Immune System Process Regulation Of Interleukin-1 Beta Production Cellular Response To Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Regulation Of Adaptive Immune Response Regulation Of Interleukin-1 Production DNA Recombination Regulation Of Apoptotic Process Activation Of Immune Response Myeloid Progenitor Cell Differentiation Intracellular Signal Transduction Regulation Of Programmed Cell Death Response To Radiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Regulation Of Immune System Process Cell Activation Involved In Immune Response Response To Lipopolysaccharide Positive Regulation Of Signal Transduction Macrophage Activation RAGE Receptor Binding Regulation Of Tumor Necrosis Factor Production Response To Stress Damaged DNA Binding Mononuclear Cell Differentiation Response To Molecule Of Bacterial Origin Regulation Of Interleukin-12 Production Cellular Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Hemopoiesis Regulation Of Developmental Process Nucleus Immune Response-activating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Response To Molecule Of Bacterial Origin
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