ZNF598 and RPS10

Number of citations of the paper that reports this interaction (PubMedID 38366554)
64

Data Source:
BioGRID (enzymatic study)

		ZNF598	RPS10
Description		zinc finger protein 598, E3 ubiquitin ligase	ribosomal protein S10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytosolic Ribosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Ribosome Binding Metal Ion Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Protein Ligase Activity Protein-RNA Adaptor Activity Stalled Ribosome Sensor Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Regulation Of Translation Protein Monoubiquitination Protein Ubiquitination Ribosome Disassembly Negative Regulation Of Translational Initiation Protein K63-linked Ubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Cytoplasmic Translation Translation
Pathways		ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS			Adult body size ( 32376654) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate ( 30604766 31015462) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494)
Interacting Genes		8 interacting genes: CDA CXCL8 DBN1 RPS10 RPS20 RPS3 UBE2D1 UBE2D3	19 interacting genes: APP DMPK DNMT3B DUX4 DVL3 EED FBXO25 HAP1 HIP1 KAT7 MKRN1 PFN2 PTTG1 RNF10 SYK TCF25 WIZ XRCC6 ZNF598
Entrez ID		90850	6204
HPRD ID		11732	04697
Ensembl ID		ENSG00000167962	ENSG00000124614
Uniprot IDs		A0AAG2UWE8 Q86UK7	P46783
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7QVP 7R4X 7TQL 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Small Ribosomal Subunit Ribosome Ubiquitin Conjugating Enzyme Activity Regulation Of Cell Communication Regulation Of Signaling Response To TNF Agonist Oxidized Pyrimidine DNA Binding Negative Regulation Of BMP Signaling Pathway Translation Cellular Response To External Biotic Stimulus Cytosine Metabolic Process Cell Communication By Chemical Coupling Interleukin-8 Receptor Binding Positive Regulation Of Base-excision Repair Ribonucleoprotein Complex Cellular Response To Tumor Necrosis Factor Nucleoside Binding Regulation Of Signal Transduction Positive Regulation Of Endodeoxyribonuclease Activity Protein K48-linked Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Receptor Localization To Synapse Response To Tumor Necrosis Factor Positive Regulation Of Deoxyribonuclease Activity NF-kappaB Complex Regulation Of Base-excision Repair Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Cycloheximide Negative Regulation Of Macromolecule Biosynthetic Process UMP Salvage Pyrimidine Ribonucleotide Salvage Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Biosynthetic Process Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Presynapse Regulation Of Superoxide Anion Generation Regulation Of Primary Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Macromolecule Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Regulation Of Receptor Internalization Nucleus Positive Regulation Of Superoxide Anion Generation Protein Stabilization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nervous System Process Regulation Of Receptor-mediated Endocytosis Molecular Function Activator Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Cell Differentiation Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Calcium-mediated Signaling Amylin Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Regulation Of Superoxide Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Receptor Internalization Cytoplasm Frizzled Binding Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Regulation Of Protein Stability Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of ERBB Signaling Pathway Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Positive Regulation Of Neurotrophin Production Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Positive Regulation Of DNA Replication Rescue Of Stalled Ribosome Ribosome Disassembly
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