ZNF598

Description		zinc finger protein 598, E3 ubiquitin ligase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Ribosome Binding Metal Ion Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Protein Ligase Activity Protein-RNA Adaptor Activity Stalled Ribosome Sensor Activity
	Biological Process	Regulation Of Translation Protein Monoubiquitination Protein Ubiquitination Ribosome Disassembly Negative Regulation Of Translational Initiation Protein K63-linked Ubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: GLIS2
Interacting Genes		8 interacting genes: CDA CXCL8 DBN1 RPS10 RPS20 RPS3 UBE2D1 UBE2D3
Entrez ID		90850
HPRD ID		11732
Ensembl ID		ENSG00000167962
Uniprot IDs		A0AAG2UWE8 Q86UK7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Small Ribosomal Subunit Ribosome Ubiquitin Conjugating Enzyme Activity Regulation Of Cell Communication Regulation Of Signaling Response To TNF Agonist Oxidized Pyrimidine DNA Binding Negative Regulation Of BMP Signaling Pathway Translation Cellular Response To External Biotic Stimulus Cytosine Metabolic Process Cell Communication By Chemical Coupling Interleukin-8 Receptor Binding Positive Regulation Of Base-excision Repair Ribonucleoprotein Complex Cellular Response To Tumor Necrosis Factor Nucleoside Binding Regulation Of Signal Transduction Positive Regulation Of Endodeoxyribonuclease Activity Protein K48-linked Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Receptor Localization To Synapse Response To Tumor Necrosis Factor Positive Regulation Of Deoxyribonuclease Activity NF-kappaB Complex Regulation Of Base-excision Repair Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Cycloheximide Negative Regulation Of Macromolecule Biosynthetic Process UMP Salvage Pyrimidine Ribonucleotide Salvage Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Biosynthetic Process Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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