LHX8 and ATF6B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX8	ATF6B
Description		LIM homeobox 8	activating transcription factor 6 beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Golgi Membrane Chromatin Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Forebrain Neuron Development Neuron Differentiation Response To Ethanol	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of ATF6-mediated Unfolded Protein Response
Pathways			ATF6B (ATF6-beta) activates chaperones ATF6B (ATF6-beta) activates chaperones
Drugs
Diseases
GWAS			A body shape index ( 34021172) Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 32469254) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		26 interacting genes: - ABI2 ATF2 ATF6B AXIN1 BANP CCHCR1 CRK CSNK2A1 EFS FIGLA FOSL2 FOXN1 GINS4 KLF3 KRT85 LDB2 NEDD9 NUTM1 PLCG2 PRPF31 SCYL3 SUV39H1 TBC1D1 TBC1D22B ZBTB24	10 interacting genes: ATF6 CDK6 CREBZF LHX8 MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1
Entrez ID		431707	1388
HPRD ID		17275	02992
Ensembl ID		ENSG00000162624	ENSG00000213676
Uniprot IDs		Q68G74	A0A1U9X796 Q6AZW6 Q99941
PDB IDs
Enriched GO Terms of Interacting Partners?		NK T Cell Differentiation Nucleus Protein Tyrosine Kinase Binding Response To Endothelin Cellular Response To Endothelin RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cell Development Signaling Adaptor Activity Response To Yeast Epigenetic Programming In The Zygotic Pronuclei DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II	ATF6-mediated Unfolded Protein Response ER-nucleus Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Transcription Regulator Complex Response To Endoplasmic Reticulum Stress Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CCAAT-binding Factor Complex Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of G2/M Transition Of Mitotic Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Lipid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process NLS-bearing Protein Import Into Nucleus Cellular Response To Stress Neuron Development Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Regulation Of Lipid Biosynthetic Process Membrane Protein Proteolysis Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Steroid Biosynthetic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress
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