DCUN1D3 and UBE2M

Number of citations of the paper that reports this interaction (PubMedID 28581483)
60

Data Source:
BioGRID (pull down)

		DCUN1D3	UBE2M
Description		defective in cullin neddylation 1 domain containing 3	ubiquitin conjugating enzyme E2 M
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytosol Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity
	Biological Process	Response To UV-C Response To Gamma Radiation Regulation Of Cell Cycle Process Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Protein Neddylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Neddylation Negative Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Postsynapse Assembly
Pathways		Neddylation	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hippocampal sclerosis ( 25188341)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		3 interacting genes: CUL2 CUL3 UBE2M	34 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL2 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 NFKBIA PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		123879	9040
HPRD ID		14660	04414
Ensembl ID		ENSG00000188215	ENSG00000130725
Uniprot IDs		Q8IWE4	A0A024R4T4 P61081
PDB IDs		4GBA	1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Complex Scaffold Activity Cullin-RING Ubiquitin Ligase Complex Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Trophectodermal Cellular Morphogenesis Intrinsic Apoptotic Signaling Pathway Liver Morphogenesis Cell Cycle Phase Transition NEDD8 Conjugating Enzyme Activity Regulation Protein Catabolic Process At Postsynapse Postsynapse POZ Domain Binding Protein Modification Process Polar Microtubule NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Nuclear Protein Quality Control By The Ubiquitin-proteasome System Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Embryonic Cleavage Fibroblast Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Proteasomal Protein Catabolic Process Negative Regulation Of Rho Protein Signal Transduction Renal Sodium Ion Transport Positive Regulation Of Mitotic Sister Chromatid Separation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Notch Binding Modification-dependent Protein Catabolic Process Contractile Actin Filament Bundle Assembly Anaphase-promoting Complex-dependent Catabolic Process Stress Fiber Assembly Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Protein Catabolic Process RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Glutamatergic Synapse Cul2-RING Ubiquitin Ligase Complex Ubiquitin-like Protein Transferase Activity Protein Neddylation Stem Cell Division Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Gland Morphogenesis	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Ubiquitination Cullin Family Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Protein Metabolic Process Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Protein Neddylation Ubiquitin Ligase Complex Scaffold Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Cytosol Cytoplasm Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Catabolic Process Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity Regulation Of Mitophagy Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion NEDD8 Transferase Activity Positive Regulation Of Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process
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