CCNT1 and GRIPAP1

Number of citations of the paper that reports this interaction (PubMedID 11704662)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CCNT1	GRIPAP1
Description		cyclin T1	GRIP1 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex	Nucleoplasm Endosome Cytosol Membrane Axon Dendrite Early Endosome Membrane Presynaptic Membrane Cell Projection Neuronal Cell Body Synapse Recycling Endosome Membrane Blood Microparticle Glutamatergic Synapse Extrinsic Component Of Postsynaptic Early Endosome Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity SnRNA Binding Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Division	Protein Transport Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Negative Regulation Of Protein Localization Negative Regulation Of Receptor Clustering
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353)	Eosinophil percentage of white cells ( 32888494)
Interacting Genes		24 interacting genes: AFF4 AHR BRD4 CDK9 ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2	70 interacting genes: AARD ANKRD11 ARL15 ATG5 BYSL CASP3 CBX8 CCDC185 CCDC187 CCNH CCNT1 CDC37 CEP57L1 CFAP53 CWF19L2 DAXX DISC1 DNAAF19 DRC4 DUSP26 EHHADH ELOA ENKD1 FAM161A FAM50B FAM90A1 FXR1 GRIA1 GRIP1 GRM7 HDAC4 HSPB1 ING4 ING5 LNX1 MAP3K1 MEOX2 MFAP1 MLLT6 NUAK2 PIBF1 PKP2 PPP1R18 PRPF18 PSMB1 RAB4A RCOR3 SMAD2 SMARCE1 SMURF1 SNAPC5 SNW1 SPP1 STAP1 TBC1D30 TCEA2 TEPSIN TES TRAF2 TSGA10IP TSHZ2 TSNAX TTC23 UBC USP2 ZMAT2 ZNF219 ZNF250 ZNF35 ZNF835
Entrez ID		904	56850
HPRD ID		03938	02325
Ensembl ID		ENSG00000129315	ENSG00000068400
Uniprot IDs		A8K4M5 O60563	Q4V328
PDB IDs		2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression 7SK SnRNA Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation SnRNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Transcription Elongation Factor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process P-TEFb Complex Binding 7SK SnRNP Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA-templated Transcription Rhythmic Process Transcription Regulator Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Transcription Coactivator Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Protein-containing Complex Positive Regulation Of Fibroblast Proliferation	Nucleoplasm Protein Binding DNA Replication-dependent Chromatin Disassembly
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