OTUD7B and ATG14

Number of citations of the paper that reports this interaction (PubMedID 37632749)
0

Data Source:
BioGRID (enzymatic study)

		OTUD7B	ATG14
Description		OTU deubiquitinase 7B	autophagy related 14
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Axoneme Membrane Cytoplasmic Vesicle Protein-containing Complex Phagophore Assembly Site Membrane Phosphatidylinositol 3-kinase Complex, Class III Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane
	Molecular Function	DNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding K48-linked Deubiquitinase Activity	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity Protein-membrane Adaptor Activity GTPase Binding Phosphatidylinositol 3-kinase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Immune System Process Mucosal Immune Response Proteolysis Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination TORC1 Signaling TORC2 Signaling Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling	Autophagosome Assembly Mitophagy Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Targeting To Lysosome Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Post-transcriptional Regulation Of Gene Expression Macroautophagy Autophagosome Membrane Docking Regulation Of Macroautophagy Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Early Endosome To Late Endosome Transport Innate Immune Response Defense Response To Virus Regulation Of Protein Complex Stability Regulation Of Triglyceride Metabolic Process Autophagosome Maturation Response To Mitochondrial Depolarisation
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases	Macroautophagy SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172)	Eosinophil percentage of white cells ( 32888494) Platelet distribution width ( 27863252) Statin-induced myopathy ( 31220337) Testicular germ cell tumor ( 28604728) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: ATG14 CCNB1 CDC20 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 OTULIN PIK3C3 PSMB1 SAXO4 SOX2 SPART TRAF6 UBC UBE2S ZDHHC17	14 interacting genes: ATG13 EXOC1 FSD2 MARCHF7 MIS18A OTUD3 OTUD7B RACK1 SNAPIN STAMBP STYK1 ULK2 USP2 YOD1
Entrez ID		56957	22863
HPRD ID		10313	13820
Ensembl ID		ENSG00000264522	ENSG00000126775
Uniprot IDs		Q6GQQ9	Q6ZNE5
PDB IDs		5LRU 5LRV 5LRW	6HOL 8SOR 9C82 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Cell Division Positive Regulation Of Post-translational Protein Modification Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Phosphatidylinositol 3-kinase Complex, Class III Ubiquitin-protein Transferase Activator Activity Proteolysis Regulation Of Protein Ubiquitination Ubiquitin Ligase Activator Activity Protein Ubiquitination Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Post-translational Protein Modification Autophagosome Assembly Cytoplasm Autophagosome Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Targeting To Lysosome Positive Regulation Of Catalytic Activity Phagophore Assembly Site Modification-dependent Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Response To DDT Cell Cycle Phase Transition Metaphase/anaphase Transition Of Meiosis I Macroautophagy Extrinsic Component Of Phagophore Assembly Site Membrane Negative Regulation Of Collateral Sprouting In Absence Of Injury Perforant Pathway To Dendrate Granule Cell Synapse Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Vacuole Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Glucose Starvation Autophagosome Maturation	Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Cysteine-type Deubiquitinase Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Protein K27-linked Deubiquitination Protein Modification Process Peptidase Activity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Piecemeal Microautophagy Of The Nucleus K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Metabolic Process Phagophore Assembly Site Membrane Microautophagy Nucleophagy Perinuclear Region Of Cytoplasm Deubiquitinase Activity Negative Regulation Of Intracellular Signal Transduction Macroautophagy Phagophore Assembly Site Cyclin Binding Vacuole Organization Negative Regulation Of Cell Projection Organization Cytosol Rescue Of Stalled Ribosome Ribosome Disassembly Cytoplasm Somatic Sensory System Development Positive Regulation Of Late Endosome To Lysosome Transport Protein Stabilization Mitophagy Translational Elongation Mitotic Cytokinesis Autophagy Autophagy Of Mitochondrion IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Negative Regulation Of Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Organelle Disassembly Autophagosome Negative Regulation Of Cellular Component Organization Hippocampal Neuron Apoptotic Process Protein K6-linked Deubiquitination Pericentric Heterochromatin Organization
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