OTUD7B and SPART

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTUD7B	SPART
Description		OTU deubiquitinase 7B	spartin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	DNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding K48-linked Deubiquitinase Activity	Protein Binding Lipid Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Immune System Process Mucosal Immune Response Proteolysis Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination TORC1 Signaling TORC2 Signaling Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling	Lipid Metabolic Process Lipid Transport Lipid Catabolic Process BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Collateral Sprouting In Absence Of Injury Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development Lipophagy Midbody Abscission Regulation Of Biological Quality
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		19 interacting genes: ATG14 CCNB1 CDC20 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 OTULIN PIK3C3 PSMB1 SAXO4 SOX2 SPART TRAF6 UBC UBE2S ZDHHC17	21 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Entrez ID		56957	23111
HPRD ID		10313	06170
Ensembl ID		ENSG00000264522	ENSG00000133104
Uniprot IDs		Q6GQQ9	A0A024RDV9 Q8N0X7
PDB IDs		5LRU 5LRV 5LRW	2DL1 4U7I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Cell Division Positive Regulation Of Post-translational Protein Modification Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Phosphatidylinositol 3-kinase Complex, Class III Ubiquitin-protein Transferase Activator Activity Proteolysis Regulation Of Protein Ubiquitination Ubiquitin Ligase Activator Activity Protein Ubiquitination Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Post-translational Protein Modification Autophagosome Assembly Cytoplasm Autophagosome Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Targeting To Lysosome Positive Regulation Of Catalytic Activity Phagophore Assembly Site Modification-dependent Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Response To DDT Cell Cycle Phase Transition Metaphase/anaphase Transition Of Meiosis I Macroautophagy Extrinsic Component Of Phagophore Assembly Site Membrane Negative Regulation Of Collateral Sprouting In Absence Of Injury Perforant Pathway To Dendrate Granule Cell Synapse Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Vacuole Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Glucose Starvation Autophagosome Maturation	Cysteine-type Deubiquitinase Activity Protein K48-linked Deubiquitination Early Endosome Membrane Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Cytosol K48-linked Deubiquitinase Activity Endosome Early Endosome Deubiquitinase Activity Protein K63-linked Deubiquitination Proteolysis Protein Modification Process Cytoplasm Endocytosis Peptidase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization Import Into Cell Protein Ubiquitination Response To Mechanical Stimulus Negative Regulation Of Leukocyte Activation Regulation Of Immune Response Neuromuscular Junction Negative Regulation Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cell Activation Protein Modification By Small Protein Conjugation K63-linked Deubiquitinase Activity Regulation Of Notch Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ubiquitin Binding Regulation Of Signaling Ubiquitin Ligase Complex Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Vesicle-mediated Transport Symbiont Entry Into Host Cell Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Transporter Activity Regulation Of Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?