CCNH and MTA1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro, in vivo)

		CCNH	MTA1
Description		cyclin H	metastasis associated 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Factor TFIIH Core Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule NuRD Complex
	Molecular Function	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Stabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Signal Transduction Response To Ionizing Radiation Circadian Regulation Of Gene Expression Regulation Of Cell Fate Specification Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Protein Autoubiquitination Regulation Of Stem Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Diastolic blood pressure ( 27841878) Fasting glucose ( 34074324) Initial pursuit acceleration ( 29064472) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Prostate cancer aggressiveness ( 25939597) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Heel bone mineral density ( 30598549)
Interacting Genes		48 interacting genes: AR BLZF1 CALCOCO2 CCDC170 CCDC33 CCNC CCT4 CDK2 CDK20 CDK3 CDK6 CDK7 CDK8 CSNK2B CTBP2 DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GRIPAP1 GTF2E2 GTF2H1 KLC3 MCM7 MCRS1 MTA1 MTMR7 NDC80 NEDD4 PICK1 POLR2A POLR2B PPFIA1 PSMA1 RARB RHOH SFN SORBS3 SSX2IP SUPT5H TCF4 TP53 TRIM8 TRIML2 ZNF655 ZNRD2	46 interacting genes: BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 DYRK1A E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SNAI1 SUMO2 TEX11 TP53 TRIM25 UBE2I ZEB2
Entrez ID		902	9112
HPRD ID		09059	04633
Ensembl ID		ENSG00000134480	ENSG00000182979
Uniprot IDs		A0A2R8YEM2 P51946	E7ESY4 Q13330 Q9BRL8
PDB IDs		1JKW 1KXU 6O9L 6XBZ 6XD3 7B5O 7B5Q 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 8BVW 8BYQ 8GXQ 8GXS 8ORM 8P6V 8P6W 8P6X 8P6Y 8P6Z 8P70 8P71 8P72 8P73 8P74 8P75 8P76 8P77 8P78 8P79 8PLZ 8PYR 8S0R 8S0T	4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16 6ZRC 6ZRD 7AO8 7AO9 7AOA
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-templated Transcription Transcription By RNA Polymerase II Nucleoplasm Nucleus DNA Damage Response Cyclin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Positive Regulation Of Macromolecule Biosynthetic Process Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation RNA-directed RNA Polymerase Activity RNA-templated Transcription Cytoplasm Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Division Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process G0 To G1 Transition TFIIB-class Transcription Factor Binding Chromatin Binding Positive Regulation Of Metabolic Process Viral Process Negative Regulation Of Stem Cell Proliferation DNA-templated Transcription Initiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle CKM Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA Repair	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Eyelid Development In Camera-type Eye Regulation Of Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Enzyme Binding NuRD Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Transcription Factor TFIIK Complex Negative Regulation Of Macromolecule Metabolic Process Developmental Process Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process CAK-ERCC2 Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Body Response To Oxidative Stress
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