CCNH and FUBP1

Number of citations: 0 (PubMedID 11239393)
Data Source: HPRD (in vitro)

		CCNH	FUBP1
Name		cyclin H	far upstream element binding protein 1
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Factor TFIIH Core Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Stabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	None
Drugs		None	Irofulven Sacituzumab govitecan
GWAS		Adult body size ( 32376654 ) Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268 ) Diastolic blood pressure ( 27841878 ) Fasting glucose ( 34074324 ) Initial pursuit acceleration ( 29064472 ) Macular thickness ( 30535121 ) Major depressive disorder ( 23377640 ) Prostate cancer aggressiveness ( 25939597 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 )	A body shape index ( 34021172 ) Age at first sexual intercourse ( 34211149 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 25673413 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Hip circumference adjusted for BMI ( 34021172 ) Lung cancer in never smokers ( 28604730 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Psoriasis ( 28537254 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		48 interacting genes: AR BLZF1 CALCOCO2 CCDC170 CCDC33 CCNC CCT4 CDK2 CDK20 CDK3 CDK6 CDK7 CDK8 CSNK2B CTBP2 DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GRIPAP1 GTF2E2 GTF2H1 KLC3 MCM7 MCRS1 MTA1 MTMR7 NDC80 NEDD4 PICK1 POLR2A POLR2B PPFIA1 PSMA1 RARB RHOH SFN SORBS3 SSX2IP SUPT5H TCF4 TP53 TRIM8 TRIML2 ZNF655 ZNRD2	25 interacting genes: AIMP2 ANXA11 CCNH CEBPA CELF1 CHD3 CRMP1 ESR1 GTF2H1 IMMT MAPK1IP1L MYOC PRPF40B PRR13 PUF60 SIRPA SMN1 SMURF2 SNRPA SNRPC TIAL1 TLE1 U2AF2 VIM VPS37C
Entrez ID		902	8880
HPRD ID		09059	10349
Ensembl ID		ENSG00000134480	ENSG00000162613
Uniprot IDs		A0A2R8YEM2 P51946	A0A384MDX9 A0A994J3Q8 B4DT31 C9JSZ1 Q96AE4
PDB IDs		1JKW 1KXU 6O9L 6XBZ 6XD3 7B5O 7B5Q 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 8BVW 8BYQ 8GXQ 8GXS 8ORM 8P6V 8P6W 8P6X 8P6Y 8P6Z 8P70 8P71 8P72 8P73 8P74 8P75 8P76 8P77 8P78 8P79 8PLZ 8PYR 8S0R 8S0T	1J4W 2KXH 4LIJ 6Y24 6Y2C 6Y2D 8P25
GO Terms Enriched among Interactors		Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-templated Transcription Transcription By RNA Polymerase II Nucleoplasm Nucleus DNA Damage Response Cyclin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Positive Regulation Of Macromolecule Biosynthetic Process Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation RNA-directed RNA Polymerase Activity RNA-templated Transcription Cytoplasm Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Division Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process G0 To G1 Transition TFIIB-class Transcription Factor Binding Chromatin Binding Positive Regulation Of Metabolic Process Viral Process Negative Regulation Of Stem Cell Proliferation DNA-templated Transcription Initiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle CKM Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA Repair	RNA Binding RNA Splicing, Via Transesterification Reactions RNA Splicing Nucleoplasm RNA Metabolic Process MRNA Processing U2-type Prespliceosome U1 SnRNP Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Metabolic Process Commitment Complex Nucleic Acid Metabolic Process U1 SnRNA Binding Nucleus Nucleobase-containing Compound Metabolic Process Transcription Factor TFIIH Core Complex Nucleic Acid Binding Transcription Factor TFIIH Holo Complex RNA Processing Transcription By RNA Polymerase I Negative Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Regulation Of MRNA Splicing, Via Spliceosome Nuclear Matrix Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Skeletal Muscle Hypertrophy Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Spliceosomal SnRNP Assembly