RRM2 and CDH1

Number of citations of the paper that reports this interaction (PMID 12655059)
47

Data Source:
HPRD (in vitro)

		RRM2	CDH1
Gene Name		ribonucleotide reductase M2	cadherin 1, type 1, E-cadherin (epithelial)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Aggresome Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Node Of Ranvier Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Axon Terminus Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Domain Specific Binding Ankyrin Binding GTPase Activating Protein Binding Gamma-catenin Binding Cell Adhesion Molecule Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Protein Heterotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Trophectodermal Cell Differentiation Epithelial Cell Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Sensory Perception Of Sound Response To Toxic Substance Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Metabolic Process Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neuron Projection Development Regulation Of Water Loss Via Skin Cell Junction Assembly Adherens Junction Organization Response To Drug Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Regulation Of Immune Response Protein Homooligomerization Intestinal Epithelial Cell Development Salivary Gland Cavitation Regulation Of Branching Involved In Salivary Gland Morphogenesis Tight Junction Assembly Cellular Response To Amino Acid Stimulus Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Development Regulation Of Protein Localization To Cell Surface Regulation Of Neuron Migration
Pathways		E2F mediated regulation of DNA replication G1/S Transition G1/S-Specific Transcription Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Mitotic G1-G1/S phases Cell Cycle, Mitotic	Cell junction organization Apoptotic cleavage of cellular proteins Adherens junctions interactions Apoptotic execution phase Degradation of the extracellular matrix Apoptotic cleavage of cell adhesion proteins Cell-cell junction organization Programmed Cell Death Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Colorectal cancer ( 19011631) Ulcerative colitis ( 19915572)
Protein-Protein Interactions		7 interactors: CDH1 CDK1 DNM1L KAT5 RRM1 RRM2B TP53	55 interactors: ACTR3 ANAPC1 ANAPC11 ANAPC4 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC16 CDC23 CDC26 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBB2IP EZR FER FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP MAD2L2 MDM2 NDRG1 NEDD9 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 TACC3 UCHL3 VCL YES1
Entrez ID		6241	999
HPRD ID		01587	01885
Ensembl ID		ENSG00000171848	ENSG00000039068
Uniprot IDs		P31350	P12830 Q9UII8
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Protein Tetramerization Protein Complex Assembly Protein Oligomerization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion DNA Damage Checkpoint Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial DNA Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Toxic Substance Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Protein Oligomerization Mitochondrial Genome Maintenance Necroptotic Process Release Of Cytochrome C From Mitochondria Positive Regulation Of Transport Cell Cycle Checkpoint Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Organelle Organization Regulation Of Protein Localization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Proteasomal Protein Catabolic Process DNA Replication Membrane Organization Cellular Component Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Programmed Necrotic Cell Death Necrotic Cell Death Apoptotic Process Positive Regulation Of Protein Transport Deoxyribonucleotide Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Single Organismal Cell-cell Adhesion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Adhesion Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Anatomical Structure Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Proteolysis Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Negative Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Catabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		antagonizing compass disparate dispensing diverge employs euchromatin fission h3k4me hulc intricacies intriguingly mat mating mst1 orthologs pericentromeric pombe relying repressing retrotransposons schizosaccharomyces set1 set1c subtelomeres subtelomeric tf2 tf2s utilizes	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		antagonizing compass disparate dispensing diverge employs euchromatin fission h3k4me hulc intricacies intriguingly mat mating mst1 orthologs pericentromeric pombe relying repressing retrotransposons schizosaccharomyces set1 set1c subtelomeres subtelomeric tf2 tf2s utilizes	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?