RRM2

Gene Name		ribonucleotide reductase M2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Protein Heterotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		E2F mediated regulation of DNA replication G1/S Transition G1/S-Specific Transcription Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-protein Interactions		7 interactors: CDH1 CDK1 DNM1L KAT5 RRM1 RRM2B TP53
Entrez ID		6241
HPRD ID		01587
Ensembl ID		ENSG00000171848
Uniprot IDs		P31350
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Protein Tetramerization Protein Complex Assembly Protein Oligomerization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion DNA Damage Checkpoint Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial DNA Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Toxic Substance Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Protein Oligomerization Mitochondrial Genome Maintenance Necroptotic Process Release Of Cytochrome C From Mitochondria Positive Regulation Of Transport Cell Cycle Checkpoint Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Organelle Organization Regulation Of Protein Localization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Proteasomal Protein Catabolic Process DNA Replication Membrane Organization Cellular Component Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Programmed Necrotic Cell Death Necrotic Cell Death Apoptotic Process Positive Regulation Of Protein Transport Deoxyribonucleotide Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		antagonizing compass disparate dispensing diverge employs euchromatin fission h3k4me hulc intricacies intriguingly mat mating mst1 orthologs pericentromeric pombe relying repressing retrotransposons schizosaccharomyces set1 set1c subtelomeres subtelomeric tf2 tf2s utilizes