RRM2 and RRM2B

Number of citations of the paper that reports this interaction (PubMedID 14729598)
0

Data Source:
HPRD (in vitro)

		RRM2	RRM2B
Description		ribonucleotide reductase regulatory subunit M2	ribonucleotide reductase regulatory TP53 inducible subunit M2B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoside-diphosphate Reductase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Blastocyst Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition	DNA Synthesis Involved In DNA Repair Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair DNA Damage Response Response To Oxidative Stress Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Amine Positive Regulation Of G0 To G1 Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040	Cladribine
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Blood protein levels ( 30072576) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Red blood cell count ( 32888494)
Interacting Genes		10 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53 USP12	9 interacting genes: CDKN1A CSNK2A1 MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		6241	50484
HPRD ID		01587	05276
Ensembl ID		ENSG00000171848	ENSG00000048392
Uniprot IDs		P31350	Q7LG56
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Mitochondrial DNA Metabolic Process Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G0 To G1 Transition Golgi Disassembly Regulation Of Mitotic Cell Cycle Positive Regulation Of Establishment Of Protein Localization Signal Transduction In Response To DNA Damage DNA-templated DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Nuclear Membrane Disassembly Mitochondrial DNA Replication Organelle Disassembly Regulation Of Metaphase Plate Congression Regulation Of Cell Cycle Phase Transition Nuclear Membrane Disassembly Regulation Of Protein Transport Regulation Of Cell Cycle Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Membrane Disassembly Positive Regulation Of Intracellular Protein Transport DNA Biosynthetic Process Carbohydrate Derivative Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Triglyceride Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process DNA Damage Response Signal Transduction By P53 Class Mediator DNA Repair Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization Positive Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Cell Cycle Phase Transition Regulation Of Attachment Of Spindle Microtubules To Kinetochore RRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Gamma Radiation Disordered Domain Specific Binding Regulation Of Cell Cycle Process Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Actinomycin D Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Response To Actinomycin D DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Gamma Radiation Regulation Of Mitotic Cell Cycle Cellular Response To UV-C Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Metabolic Process Stress-induced Premature Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Antibiotic Protein-containing Complex Assembly Protein Tetramerization Signal Transduction By P53 Class Mediator DNA Damage Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Mitophagy Cellular Response To Light Stimulus Protein-containing Complex Organization DNA Damage Response Response To UV-C Replicative Senescence Positive Regulation Of Cell Cycle Phase Transition 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Cytosol Regulation Of Signal Transduction By P53 Class Mediator Cellular Component Assembly Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process
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