RRM2 and RRM2B

Number of citations of the paper that reports this interaction (PMID 14729598)
18

Data Source:
HPRD (in vitro)

		RRM2	RRM2B
Gene Name		ribonucleotide reductase M2	ribonucleotide reductase M2 B (TP53 inducible)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Protein Heterotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		E2F mediated regulation of DNA replication G1/S Transition G1/S-Specific Transcription Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Mitotic G1-G1/S phases Cell Cycle, Mitotic	Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		7 interactors: CDH1 CDK1 DNM1L KAT5 RRM1 RRM2B TP53	5 interactors: MDM2 ORC4 RRM1 RRM2 TP53
Entrez ID		6241	50484
HPRD ID		01587	05276
Ensembl ID		ENSG00000171848	ENSG00000048392
Uniprot IDs		P31350	B4E2N4 Q7LG56
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Protein Tetramerization Protein Complex Assembly Protein Oligomerization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion DNA Damage Checkpoint Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial DNA Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Toxic Substance Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Protein Oligomerization Mitochondrial Genome Maintenance Necroptotic Process Release Of Cytochrome C From Mitochondria Positive Regulation Of Transport Cell Cycle Checkpoint Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Organelle Organization Regulation Of Protein Localization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Proteasomal Protein Catabolic Process DNA Replication Membrane Organization Cellular Component Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Programmed Necrotic Cell Death Necrotic Cell Death Apoptotic Process Positive Regulation Of Protein Transport Deoxyribonucleotide Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Cell Cycle Protein Tetramerization Deoxyribonucleotide Biosynthetic Process Mitotic Cell Cycle Process Protein Heterotetramerization Nucleobase-containing Small Molecule Interconversion DNA Replication Protein Complex Assembly Cell Cycle Process DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Deoxyribonucleotide Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV Protein Oligomerization Signal Transduction Involved In Cell Cycle Checkpoint Response To Antibiotic Response To Radiation Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Cellular Component Assembly Cellular Response To UV-C Cellular Response To Vitamin B1 Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Regulation Of Cell Cycle G1/S Phase Transition Protein Heterooligomerization Cellular Response To Radiation Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		antagonizing compass disparate dispensing diverge employs euchromatin fission h3k4me hulc intricacies intriguingly mat mating mst1 orthologs pericentromeric pombe relying repressing retrotransposons schizosaccharomyces set1 set1c subtelomeres subtelomeric tf2 tf2s utilizes	7a abcc2 carboplatin chemotoxicity dspr fecundity founder gemcitabine gpx4 inbred inpp4a intercross interindividual mitomycin msh2 multiparent nalcn nonsynonymous ortholog orthologs posteriori priori qtl revolutionize segregating singly solute transposable
Tagcloud (Difference) ?		antagonizing compass disparate dispensing diverge employs euchromatin fission h3k4me hulc intricacies intriguingly mat mating mst1 pericentromeric pombe relying repressing retrotransposons schizosaccharomyces set1 set1c subtelomeres subtelomeric tf2 tf2s utilizes	7a abcc2 carboplatin chemotoxicity dspr fecundity founder gemcitabine gpx4 inbred inpp4a intercross interindividual mitomycin msh2 multiparent nalcn nonsynonymous ortholog posteriori priori qtl revolutionize segregating singly solute transposable
Tagcloud (Intersection) ?		orthologs