TAF1C and TAF1B

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vitro)

		TAF1C	TAF1B
Name		TATA-box binding protein associated factor, RNA polymerase I subunit C	TATA-box binding protein associated factor, RNA polymerase I subunit B
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus	RNA Polymerase I Transcription Regulator Complex Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus RNA Polymerase I Core Factor Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Transcription By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
GWAS		Autism ( 22843504 ) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872 ) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 ) Visceral adipose tissue adjusted for BMI ( 22589738 )	Dental caries (decayed, missing and filled teeth) ( 31533690 ) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 ) Egg allergy (maternal genetic effects) ( 29489655 ) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Prostate cancer ( 23535732 )
Novel Interactors		None recorded	1 novel interactors: RRM2
Interacting Genes		14 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1 VPS26C	26 interacting genes: ACADVL APP CALR EP300 ESR1 H2AC20 H2BC21 H3C1 H4C1 MEOX2 MYC NAPB NEDD4 NEDD4L PGR RRN3 RXRA SRPK1 TAF1A TAF1C TBP THAP7 TP53 TRB TRIM24 UBTF
Entrez ID		9013	9014
HPRD ID		05364	05363
Ensembl ID		ENSG00000103168	ENSG00000115750
Uniprot IDs		B3KUE8 Q15572	Q53T94
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase I Transcription Preinitiation Complex Assembly Protein-DNA Complex Assembly RNA Polymerase Transcription Factor SL1 Complex Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization DNA-templated Transcription Initiation RRNA Transcription RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I General Transcription Initiation Factor Activity Male Germ Cell Nucleus Macromolecule Metabolic Process Nucleoplasm Cellular Component Assembly Nucleus Regulation Of DNA-templated Transcription Initiation Nucleolus DNA Binding Core Promoter Sequence-specific DNA Binding Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Fibroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Histone H3K23ac Reader Activity RNA Polymerase I Core Factor Complex RNA Polymerase I General Transcription Initiation Factor Binding RRNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Euchromatin MRNA Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Thymidine Kinase Activity Oligodendrocyte Apoptotic Process P53 Binding Negative Regulation Of Pentose-phosphate Shunt	DNA Binding DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Protein-containing Complex Organization Transcription By RNA Polymerase II Protein-DNA Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Chromatin Organization Nucleoplasm Protein-containing Complex Assembly Chromatin RNA Polymerase Transcription Factor SL1 Complex RNA Polymerase I General Transcription Initiation Factor Activity RNA Metabolic Process Transcription Preinitiation Complex Assembly Macromolecule Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein-containing Complex Transcription Initiation At RNA Polymerase I Promoter Nucleus Chromatin Remodeling Nuclear Receptor-mediated Signaling Pathway Transcription Coregulator Binding Estrogen Response Element Binding Transcription Coactivator Binding Regulation Of Signal Transduction By P53 Class Mediator Transcription By RNA Polymerase I Enzyme Binding Euchromatin Core Promoter Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Hormone-mediated Signaling Pathway Nucleic Acid Metabolic Process Cellular Component Assembly Epigenetic Regulation Of Gene Expression Nuclear Steroid Receptor Activity Regulation Of MiRNA Transcription DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Initiation Structural Constituent Of Chromatin Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To UV Regulation Of MiRNA Metabolic Process