TAF1C and UBTF

Number of citations of the paper that reports this interaction (PubMedID 10913176)
53

Data Source:
BioGRID (pull down)

		TAF1C	UBTF
Description		TATA-box binding protein associated factor, RNA polymerase I subunit C	upstream binding transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways		SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Autism ( 22843504) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Visceral adipose tissue adjusted for BMI ( 22589738)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) hemolysis of donated blood (osmotic) ( 34014839) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		14 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1 VPS26C	37 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CEBPA CENPC CHGB CREBBP CSNK2A1 EP300 GSK3A IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RNF10 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 USP7 ZMYM2
Entrez ID		9013	7343
HPRD ID		05364	02814
Ensembl ID		ENSG00000103168	ENSG00000108312
Uniprot IDs		B3KUE8 Q15572	P17480
PDB IDs			1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase I Transcription Preinitiation Complex Assembly Protein-DNA Complex Assembly RNA Polymerase Transcription Factor SL1 Complex Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization DNA-templated Transcription Initiation RRNA Transcription RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I General Transcription Initiation Factor Activity Male Germ Cell Nucleus Macromolecule Metabolic Process Nucleoplasm Cellular Component Assembly Nucleus Regulation Of DNA-templated Transcription Initiation Nucleolus DNA Binding Core Promoter Sequence-specific DNA Binding Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Fibroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Histone H3K23ac Reader Activity RNA Polymerase I Core Factor Complex RNA Polymerase I General Transcription Initiation Factor Binding RRNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Euchromatin MRNA Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Thymidine Kinase Activity Oligodendrocyte Apoptotic Process P53 Binding Negative Regulation Of Pentose-phosphate Shunt	Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase Transcription Factor SL1 Complex Nucleoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Transcription Initiation At RNA Polymerase I Promoter Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process RNA Polymerase I Preinitiation Complex Assembly Regulation Of Proteolysis RNA Metabolic Process RNA Polymerase I Transcription Regulator Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Macromolecule Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Cell Division Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Gland Development DNA-binding Transcription Factor Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle
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