TAF1C and POLR1E

Number of citations of the paper that reports this interaction (PubMedID 15226435)
57

Data Source:
HPRD (in vitro)

		TAF1C	POLR1E
Description		TATA-box binding protein associated factor, RNA polymerase I subunit C	RNA polymerase I subunit E
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Nucleolus RNA Polymerase I Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Protein Binding	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Transcription Elongation By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Autism ( 22843504) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		14 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1 VPS26C	9 interacting genes: NFKBIB OGT POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF
Entrez ID		9013	64425
HPRD ID		05364	15096
Ensembl ID		ENSG00000103168	ENSG00000137054
Uniprot IDs		B3KUE8 Q15572	B4E005 Q9GZS1
PDB IDs			7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase I Transcription Preinitiation Complex Assembly Protein-DNA Complex Assembly RNA Polymerase Transcription Factor SL1 Complex Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization DNA-templated Transcription Initiation RRNA Transcription RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I General Transcription Initiation Factor Activity Male Germ Cell Nucleus Macromolecule Metabolic Process Nucleoplasm Cellular Component Assembly Nucleus Regulation Of DNA-templated Transcription Initiation Nucleolus DNA Binding Core Promoter Sequence-specific DNA Binding Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Fibroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Histone H3K23ac Reader Activity RNA Polymerase I Core Factor Complex RNA Polymerase I General Transcription Initiation Factor Binding RRNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Euchromatin MRNA Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Thymidine Kinase Activity Oligodendrocyte Apoptotic Process P53 Binding Negative Regulation Of Pentose-phosphate Shunt	Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase I Complex RRNA Transcription Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA-directed RNA Polymerase Complex Transcription Initiation At RNA Polymerase I Promoter Fibrillar Center RNA Metabolic Process Nucleolus DNA-directed RNA Polymerase Activity Nucleic Acid Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RRNA Metabolic Process DNA-templated Transcription Initiation RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase I Nucleoplasm Regulation Of Transcription By RNA Polymerase I Regulation Of Gluconeogenesis Chromosome Transcription Preinitiation Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleolus Organizer Region Negative Regulation Of Protein Ubiquitination Nucleus RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Localization To Nucleolus Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Protein-glutaryllysine Deglutarylase Activity Nucleologenesis Negative Regulation Of Post-translational Protein Modification Nucleotidyltransferase Activity Regulation Of Glucose Metabolic Process Protein O-acetylglucosaminyltransferase Activity RNA Polymerase I Transcription Regulator Complex Ribonucleoside Binding Chromatin Binding Regulation Of Glucose Mediated Signaling Pathway
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