KIF16B and GINS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIF16B	GINS4
Description		kinesin family member 16B	GINS complex subunit 4
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Cytoplasmic Vesicle Early Endosome Membrane	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Lipid Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding
	Biological Process	Formation Of Primary Germ Layer Regulation Of Receptor Recycling Golgi To Endosome Transport Microtubule-based Movement Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Endoderm Development Fibroblast Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Receptor Catabolic Process Early Endosome To Late Endosome Transport Vesicle Transport Along Microtubule	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Replication DNA-templated DNA Replication
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Asthma ( 27611488) Body mass index ( 26426971) Chronotype ( 30696823) Dimensional psychopathology (Positive) ( 29496196) Emphysema imaging phenotypes ( 26030696) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) HDL cholesterol levels in HIV infection ( 33109212) Hodgkin's lymphoma ( 34216518) Ileal carcinoids ( 21139019) Intelligence ( 22449649) LDL cholesterol levels in HIV infection ( 33109212) Lipid traits ( 30576415) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Sweet taste preference ( 32572145)
Interacting Genes		10 interacting genes: GABARAPL2 GINS4 IL16 ITSN1 LGALS3 PRKAA1 PRKAA2 SMYD1 TCEANC TSR2	12 interacting genes: - BIN3 CTNNBIP1 DMAP1 GINS2 KIF16B LHX8 PBX4 POLA1 POLD1 POLE PPP1R13B
Entrez ID		55614	84296
HPRD ID		10731	11583
Ensembl ID		ENSG00000089177	ENSG00000147536
Uniprot IDs		A0A140VK74 A0A1B0GTU3 A0A1B0GVS8 Q96L93	Q9BRT9
PDB IDs		2V14 6EE0	2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?		Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Lipid Droplet Negative Regulation Of Tubulin Deacetylation Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Cellular Response To Prostaglandin E Stimulus Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein K6-linked Ubiquitination Response To Prostaglandin E Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Cellular Response To Starvation Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process Lipid Droplet Organization Response To Starvation Sterol Biosynthetic Process Regulation Of Release Of Cytochrome C From Mitochondria Epithelial Cell Apoptotic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Cellular Response To Glucose Starvation Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Regulation Of Epithelial Cell Apoptotic Process Protein Localization To Lysosome Cellular Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Cellular Response To Xenobiotic Stimulus Autophagy Negative Regulation Of Glucosylceramide Biosynthetic Process Cellular Response To Glucose Stimulus Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Phosphatidylcholine Metabolic Process TORC1 Signaling Energy Homeostasis	DNA Polymerase Activity DNA-directed DNA Polymerase Activity DNA Replication Proofreading DNA Synthesis Involved In DNA Repair Leading Strand Elongation DNA Replication DNA-templated DNA Replication Nucleotide-excision Repair, DNA Gap Filling DNA Repair DNA Strand Elongation Involved In DNA Replication Nucleotidyltransferase Activity DNA Biosynthetic Process Base-excision Repair, Gap-filling DNA Strand Elongation DNA Metabolic Process DNA Damage Response 4 Iron, 4 Sulfur Cluster Binding Actin Cortical Patch Localization Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Iron-sulfur Cluster Binding Beta-catenin-ICAT Complex Indoleamine 2,3-dioxygenase Activity Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Unidimensional Cell Growth Tryptophan 2,3-dioxygenase Activity Mitotic DNA Replication Initiation Nucleobase-containing Compound Biosynthetic Process Alpha DNA Polymerase:primase Complex Error-free Translesion Synthesis Delta DNA Polymerase Complex Epsilon DNA Polymerase Complex Single-stranded DNA 3'-5' DNA Exonuclease Activity GINS Complex Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Ethanol L-tryptophan Catabolic Process To Kynurenine Cellular Response To Stress DNA Replication, Synthesis Of Primer Nucleotide-excision Repair Complex Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II
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