PHLDB2 and FLNC

Number of citations of the paper that reports this interaction (PMID 12376540)
12

Data Source:
HPRD (in vitro, in vivo)

		PHLDB2	FLNC
Gene Name		pleckstrin homology-like domain, family B, member 2	filamin C, gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Intermediate Filament Cytoskeleton	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Protein Binding	Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process		Cell Junction Assembly Muscle Fiber Development
Pathways			Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		4 interactors: FLNC USP7 YWHAG YWHAQ	29 interactors: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 INPPL1 KCND2 KY MAP2K4 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		90102	2318
HPRD ID		06611	00018
Ensembl ID		ENSG00000144824	ENSG00000128591
Uniprot IDs		E9PGF6 Q86SQ0	Q14315 Q59H94
PDB IDs			1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Maintenance Of DNA Methylation Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Developmental Process Histone Deubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Substantia Nigra Development Regulation Of Protein Localization Transcription-coupled Nucleotide-excision Repair Membrane Organization Muscle Fiber Development Intracellular Protein Transport Regulation Of Organelle Organization	Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Muscle Cell Development Blood Circulation Muscle Structure Development Heart Development Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Cardiovascular System Development Positive Regulation Of Systemic Arterial Blood Pressure Adrenergic Receptor Signaling Pathway Muscle Cell Differentiation Regulation Of Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cardiac Muscle Tissue Development Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Organ Development Multicellular Organismal Development Developmental Process Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Muscle Organ Development Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Peptidyl-threonine Phosphorylation Striated Muscle Tissue Development Striated Muscle Cell Development System Development Muscle Tissue Development Regulation Of Heart Contraction Anatomical Structure Development Actin Cytoskeleton Organization Regulation Of The Force Of Heart Contraction By Chemical Signal Heart Contraction Actin Filament-based Process Myofibril Assembly Cell Development Regulation Of Blood Vessel Size Cellular Response To Carbohydrate Stimulus Regulation Of Tube Size Striated Muscle Cell Differentiation Adult Heart Development Muscle System Process Signaling Organ Growth Actomyosin Structure Organization Cell Communication Positive Regulation Of Heart Rate Peptidyl-serine Phosphorylation
Tagcloud ?			adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?			adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?