CCNG1 and PTPA

Number of citations of the paper that reports this interaction (PubMedID 8887688)
47

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		CCNG1	PTPA
Description		cyclin G1	protein phosphatase 2 phosphatase activator
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Division	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process
Pathways		Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Aortic vascular smooth muscle cell proliferation in response to IL-1 beta ( 33040646) HIV progression (CD4 and viral load) ( 28132517) Metabolite levels ( 31628463) Plasma anti-thyroglobulin levels ( 29678681) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		28 interacting genes: APP CBY2 CCDC125 CDK5 CDKN2A DRC4 GAK GRN HMBOX1 KRT40 KRTAP10-7 LMNA LTBP3 LZTS2 MDM2 MT-CO2 NFATC4 PAK5 PLEKHA4 PNMA1 PPP2CA PTPA RBPMS SHKBP1 TFAP2C TFIP11 TNIP1 TP53	32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT
Entrez ID		900	5524
HPRD ID		03345	02858
Ensembl ID		ENSG00000113328	ENSG00000119383
Uniprot IDs		P51959	F6WIT2 Q15257
PDB IDs			2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Identical Protein Binding P53 Binding Disordered Domain Specific Binding Cellular Response To Actinomycin D Amyloid Fibril Formation Astrocyte Activation Involved In Immune Response Response To Actinomycin D Cellular Response To UV-C Regulation Of Proteolysis Regulation Of Protein Export From Nucleus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Negative Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Negative Regulation Of Multicellular Organismal Process Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Proteolysis Regulation Of Protein Localization To Nucleus Negative Regulation Of Cellular Component Organization Cellular Response To Antibiotic Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Response To Light Stimulus Negative Regulation Of Wnt Signaling Pathway Regulation Of Carbohydrate Catabolic Process MDM2/MDM4 Family Protein Binding Cellular Senescence Regulation Of Cell Population Proliferation Regulation Of Cellular Response To Stress Negative Regulation Of Cell Projection Organization Protein Localization To Nucleus Regulation Of Cell Cycle G1/S Phase Transition Response To UV-C Regulation Of Cellular Component Organization Regulation Of MiRNA Transcription Replicative Senescence Regulation Of Protein Stability	Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor
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