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GFI1B
Description
growth factor independent 1B transcriptional repressor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Plasma Membrane
Nuclear Matrix
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Hemopoiesis
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS
Basophil percentage of white cells (
27863252
)
Cardiometabolic and hematological traits (
27668658
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Granulocyte count (
27863252
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean platelet volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Myeloid white cell count (
27863252
)
Myeloproliferative neoplasms (
33057200
)
Neutrophil count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma factor V levels in venous thrombosis (conditioned on rs6027) (
31271701
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
27863252
32888494
)
Red blood cell count (
32888494
)
Red cell distribution width (
28957414
27863252
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Sum eosinophil basophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
27863252
32888494
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
72 interacting genes:
ACTN1
AGRN
AJUBA
ANKS3
ATXN2
BABAM2
BECN1
BEGAIN
BEND5
BRCA1
CCDC136
CCDC85B
CENPB
COPS5
CPAP
DNAJA3
DTNA
DZANK1
EFEMP1
EFEMP2
EGFL7
FBLN1
FBLN5
GPAT4
GRIP2
GRN
HECW1
HGS
HNRNPK
HSPG2
IFFO1
JAG2
KALRN
KIF17
LAMB1
LTBP4
LZTS2
MATR3
MEGF6
MEGF8
MID2
MON1A
MYH14
NELL1
NELL2
NOTCH1
NSMF
PDE4DIP
PDLIM5
PDZD4
PHC2
PICK1
POLR1H
PSMA3
RAB11FIP4
RCHY1
RCOR1
RINT1
RNF31
RUNDC3A
TAF1
TLE5
TMF1
TNS2
TRAF1
TRIM27
TRIP6
TSPYL2
TXNDC11
USHBP1
VSNL1
ZNRF3
Entrez ID
8328
HPRD ID
05088
Ensembl ID
ENSG00000165702
Uniprot IDs
A0A024R8F3
Q5VTD9
PDB IDs
Enriched GO Terms of Interacting Partners
?
Calcium Ion Binding
Regulation Of Cell Communication
Regulation Of Signaling
Elastic Fiber
Regulation Of Signal Transduction
Extracellular Matrix Structural Constituent
Elastic Fiber Assembly
Transcription Coactivator Activity
Integrin Binding
Embryo Implantation
Basement Membrane
Auditory Receptor Cell Fate Commitment
Protein Kinase C Binding
Extracellular Matrix
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Focal Adhesion Assembly
Regulation Of Growth
Protein Binding
Developmental Process
Extracellular Matrix Assembly
Nuclear Ubiquitin Ligase Complex
Negative Regulation Of Canonical Wnt Signaling Pathway
Mitotic G2 DNA Damage Checkpoint Signaling
Stress Fiber
BRCA1-A Complex
Cell-substrate Junction Assembly
Protein Modification By Small Protein Conjugation
Cell-substrate Junction Organization
Negative Regulation Of Signal Transduction
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Ubiquitin Protein Ligase Activity
Negative Regulation Of Wnt Signaling Pathway
Cytoplasm
Identical Protein Binding
Regulation Of Cellular Component Organization
Regulation Of Anatomical Structure Morphogenesis
Negative Regulation Of Cell Population Proliferation
Neuronal Ion Channel Clustering
Astral Microtubule Organization
Regulation Of Programmed Cell Death
Protein Ubiquitination
Vascular Associated Smooth Muscle Cell Development
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