RPS6KA4 and CREB1

Number of citations of the paper that reports this interaction (PubMedID 9687510)
44

Data Source:
HPRD (in vitro)

		RPS6KA4	CREB1
Description		ribosomal protein S6 kinase A4	cAMP responsive element binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrial Matrix Centrosome Cytosol Axon Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Hsp70 Protein Binding Histone Acetyltransferase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Arrestin Family Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway	Response To Hypoxia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Axonogenesis Lactation Memory Circadian Rhythm Regulation Of Cell Size Visual Learning Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Response To Purine-containing Compound Response To Activity Pituitary Gland Development Cell Differentiation Osteoclast Differentiation Mammary Gland Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Response To Glucagon Chemotaxis To Arachidonate Response To Nicotine Cellular Response To Hepatocyte Growth Factor Stimulus Response To Erythropoietin Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Response To Cocaine MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Hormone Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fibroblast Proliferation Rhythmic Process Protein Stabilization Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Glial Cell Proliferation Lung Epithelium Development Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Fatty Acid Cellular Response To Transforming Growth Factor Beta Stimulus CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Response To L-glutamate Response To Dehydroepiandrosterone Positive Regulation Of Membrane Depolarization Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Response To Hypobaric Hypoxia Regulation Of Testosterone Biosynthetic Process
Pathways		Recycling pathway of L1
Drugs		Flavin mononucleotide	Adenosine phosphate Naloxone
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Offspring birth weight ( 31043758) Primary biliary cholangitis ( 21399635) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Serum uric acid levels ( 32514006)	Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) Food antigen IgG levels ( 24962563) Mean corpuscular hemoglobin ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 27841878)
Interacting Genes		9 interacting genes: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4	86 interacting genes: ABL1 AGR2 AKT1 ATF1 ATF6 ATF7IP ATM ATR BRD10 CAMK2A CCDC6 CDK1 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 CRTC2 CSNK1D CSNK2A1 CSNK2B DNMT3L DYRK1A EDF1 ERG28 ETS1 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HIVEP1 HNF1B HPS6 KAT5 KCNIP3 MAPK14 MAPKAPK2 MTF2 NR3C1 PDX1 PIAS1 PIAS2 POGZ POU2F1 PPP1CA PRKACA PRKG1 PTEN RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RNF4 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SMCO1 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92
Entrez ID		8986	1385
HPRD ID		04677	00442
Ensembl ID		ENSG00000162302	ENSG00000118260
Uniprot IDs		A0PJF8 B4DPV1 E9PJN1 O75676	B7Z5C6 P16220 Q53X93 Q5U0J5
PDB IDs			2LXT 5ZK1 5ZKO 7TBH
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Intracellular Signaling Cassette Regulation Of Transcription By RNA Polymerase II Trachea Formation Response To Growth Factor Intracellular Signal Transduction ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MAP Kinase Activity Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Nucleobase-containing Compound Metabolic Process Response To Peptide Response To Cytokine Regulation Of Intracellular Transport Cellular Response To Tumor Necrosis Factor Face Development Animal Organ Formation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Biosynthetic Process Response To Tumor Necrosis Factor Response To Light Stimulus Enzyme-linked Receptor Protein Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Interleukin-34-mediated Signaling Pathway Response To Purine-containing Compound Regulation Of Stress-activated MAPK Cascade Myeloid Leukocyte Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Lipid ATF4-CREB1 Transcription Factor Complex DNA-templated Transcription Regulation Of Gene Expression Osteoclast Differentiation Response To Radiation	Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Protein Kinase Activity PML Body Kinase Activity Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation ATP Binding Transferase Activity Chromatin Remodeling Phosphorylation Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of CREB Transcription Factor Activity DNA-binding Transcription Factor Activity Chromatin Organization Sequence-specific DNA Binding Nucleic Acid Metabolic Process Intracellular Signal Transduction
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