RPS6KA4 and ATF1

Number of citations of the paper that reports this interaction (PMID 11909979)
101

Data Source:
HPRD (in vitro)

		RPS6KA4	ATF1
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 4	activating transcription factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase P38 Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Complex Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Axon Guidance Histone Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways		Axon guidance L1CAM interactions Recycling pathway of L1	CREB phosphorylation Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Primary biliary cirrhosis ( 21399635)	Colorectal cancer ( 20972440) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		9 interactors: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4	20 interactors: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B EDF1 GABPA GABPB1 HNF1B JUN PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		8986	466
HPRD ID		04677	00440
Ensembl ID		ENSG00000162302	ENSG00000123268
Uniprot IDs		A0PJF8 E9PJN1 G3XAA9 O75676	P18846
PDB IDs
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Cellular Response To Stress Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Golgi Inheritance Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Immune Response Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Golgi Organization Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Immune Response Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Early Endosome To Late Endosome Transport Fc-epsilon Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Fc Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Process Regulation Of Immune System Process	Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Developmental Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Protein Phosphorylation Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Histone Acetylation Phosphorylation Response To Cytokine RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Axon Development Regulation Of Myeloid Cell Differentiation Gene Expression Chemotaxis Positive Regulation Of Histone Acetylation Negative Regulation Of Gene Expression Nervous System Development Cell Development Cellular Macromolecule Biosynthetic Process Axon Guidance Apoptotic Process Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Positive Regulation Of Protein Acetylation Programmed Cell Death Anatomical Structure Morphogenesis
Tagcloud ?		bay11 biogenic blockade carrying collectively colorectal enhancing etoposide evident exerts fluorouracil hct116 irradiation la lipoic marked p90s6k polyneuropathy preventing proapoptotic restoration ribosomal stabilizing stresses suppresses tnfalpha transfection triggered uvc	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated
Tagcloud (Difference) ?		bay11 biogenic blockade carrying collectively colorectal enhancing etoposide evident exerts fluorouracil hct116 irradiation la lipoic marked p90s6k polyneuropathy preventing proapoptotic restoration ribosomal stabilizing stresses tnfalpha transfection triggered uvc	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk unstimulated
Tagcloud (Intersection) ?		suppresses