RPS6KA4 and ATF1

Number of citations of the paper that reports this interaction (PubMedID 11909979)
46

Data Source:
HPRD (in vitro)

		RPS6KA4	ATF1
Description		ribosomal protein S6 kinase A4	activating transcription factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Response To Purine-containing Compound Response To Cobalt Ion Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly CAMP/PKA Signal Transduction
Pathways		Recycling pathway of L1	CREB phosphorylation NGF-stimulated transcription NGF-stimulated transcription
Drugs		Flavin mononucleotide	Pseudoephedrine
Diseases			Clear cell sarcoma of soft tissue
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Offspring birth weight ( 31043758) Primary biliary cholangitis ( 21399635) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Serum uric acid levels ( 32514006)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 25990418 24737748 20972440) Colorectal cancer or advanced adenoma ( 30510241) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Male-pattern baldness ( 27182965) Mean arterial pressure ( 27618448) Multiple sclerosis ( 31604244) Spleen volume ( 34128465) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 30578418)
Interacting Genes		9 interacting genes: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4	23 interacting genes: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B DNMT3L EDF1 GABPA GABPB1 HNF1B JUN MAPKAPK2 MAPKAPK3 PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		8986	466
HPRD ID		04677	00440
Ensembl ID		ENSG00000162302	ENSG00000123268
Uniprot IDs		A0PJF8 B4DPV1 E9PJN1 O75676	P18846
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Intracellular Signaling Cassette Regulation Of Transcription By RNA Polymerase II Trachea Formation Response To Growth Factor Intracellular Signal Transduction ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MAP Kinase Activity Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Nucleobase-containing Compound Metabolic Process Response To Peptide Response To Cytokine Regulation Of Intracellular Transport Cellular Response To Tumor Necrosis Factor Face Development Animal Organ Formation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Biosynthetic Process Response To Tumor Necrosis Factor Response To Light Stimulus Enzyme-linked Receptor Protein Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Interleukin-34-mediated Signaling Pathway Response To Purine-containing Compound Regulation Of Stress-activated MAPK Cascade Myeloid Leukocyte Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Lipid ATF4-CREB1 Transcription Factor Complex DNA-templated Transcription Regulation Of Gene Expression Osteoclast Differentiation Response To Radiation	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Nucleoplasm Protein Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Kinase CK2 Complex Kinase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Calmodulin Binding CAMP/PKA Signal Transduction Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Transferase Activity Phosphorylation Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Negative Regulation Of Biosynthetic Process Histone H3S28 Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding ATP Binding Chromatin Symbiont-mediated Disruption Of Host Cell PML Body
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