WNT3A and RYK

Number of citations of the paper that reports this interaction (PMID 15454084)
100

Data Source:
HPRD (in vitro)

		WNT3A	RYK
Gene Name		wingless-type MMTV integration site family, member 3A	receptor-like tyrosine kinase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Early Endosome Membrane	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity Frizzled Binding Frizzled-2 Binding Protein Binding Protein Domain Specific Binding Receptor Agonist Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Receptor Internalization Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Axon Guidance Positive Regulation Of Cell Proliferation COP9 Signalosome Assembly Negative Regulation Of Neuron Projection Development Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Hemopoiesis Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Positive Regulation Of Catenin Import Into Nucleus Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Inner Ear Morphogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Palate Development Canonical Wnt Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Dermatome Development Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation	Protein Phosphorylation Signal Transduction Axon Guidance Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Corpus Callosum Development Neuron Differentiation Neuron Projection Development Positive Regulation Of MAPK Cascade
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors)	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2	5 interactors: EPHB2 EPHB3 FZD8 WNT1 WNT3A
Entrez ID		89780	6259
HPRD ID		05897	02751
Ensembl ID		ENSG00000154342	ENSG00000163785
Uniprot IDs		P56704	P34925 Q59FQ5 Q8WTZ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Receptor Localization To Synapse Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell-cell Signaling Protein Localization To Synapse Anatomical Structure Morphogenesis Canonical Wnt Signaling Pathway Neuron Differentiation Signaling Tissue Morphogenesis Regulation Of Embryonic Development Cell Communication Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway System Development Regulation Of Signaling Nervous System Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Wnt Signaling Pathway Generation Of Neurons Receptor Clustering Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurogenesis Nucleotide Phosphorylation Organ Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Hard Palate Development Signal Transduction Morphogenesis Of A Branching Epithelium Epithelium Development Ureteric Bud Morphogenesis Negative Regulation Of Signal Transduction Morphogenesis Of A Branching Structure Developmental Process Negative Regulation Of Signaling Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of BMP Signaling Pathway Stem Cell Proliferation Positive Regulation Of Signal Transduction Response To Stimulus Tube Development Cell Morphogenesis Involved In Differentiation Renal Tubule Development Cell Proliferation	Central Nervous System Neuron Differentiation Positive Regulation Of Dermatome Development Anatomical Structure Formation Involved In Morphogenesis Neuron Differentiation Forebrain Development Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Cell Projection Organization Palate Development Generation Of Neurons Ear Morphogenesis Neurogenesis Dendritic Spine Morphogenesis Regulation Of Axonogenesis Spinal Cord Association Neuron Differentiation Immune System Development Inner Ear Development Corpus Callosum Development Dendritic Spine Development Brain Development Head Development Retinal Ganglion Cell Axon Guidance Dendritic Spine Organization Dorsal Spinal Cord Development Nervous System Development Cardiovascular System Development Ear Development Axonal Fasciculation Anatomical Structure Morphogenesis Central Nervous System Development Wnt Signaling Pathway Telencephalon Development Positive Regulation Of Embryonic Development Positive Regulation Of Synapse Assembly Positive Regulation Of Cellular Component Biogenesis Neuron Recognition Embryonic Organ Morphogenesis Homotypic Cell-cell Adhesion Angiogenesis Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Receptor Activity Cell Adhesion Organ Development Regulation Of Cell-cell Adhesion Regulation Of Signaling Regulation Of Neuron Projection Development Urogenital System Development Cell Surface Receptor Signaling Pathway Axon Guidance Blood Vessel Morphogenesis
Tagcloud ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak
Tagcloud (Difference) ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak
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