WNT3A and GPC3

Number of citations of the paper that reports this interaction (PMID 16227623)
18

Data Source:
HPRD (in vivo)

		WNT3A	GPC3
Gene Name		wingless-type MMTV integration site family, member 3A	glypican 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Early Endosome Membrane	Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Frizzled Binding Frizzled-2 Binding Protein Binding Protein Domain Specific Binding Receptor Agonist Activity	Protein Binding Heparan Sulfate Proteoglycan Binding Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Receptor Internalization Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Axon Guidance Positive Regulation Of Cell Proliferation COP9 Signalosome Assembly Negative Regulation Of Neuron Projection Development Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Hemopoiesis Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Positive Regulation Of Catenin Import Into Nucleus Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Inner Ear Morphogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Palate Development Canonical Wnt Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Dermatome Development Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation	Retinoid Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Body Morphogenesis Negative Regulation Of Peptidase Activity Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Small Molecule Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Coronary Vasculature Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors)	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2	4 interactors: FGF2 IGF2 WNT3A WNT7B
Entrez ID		89780	2719
HPRD ID		05897	02074
Ensembl ID		ENSG00000154342	ENSG00000147257
Uniprot IDs		P56704	B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Receptor Localization To Synapse Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell-cell Signaling Protein Localization To Synapse Anatomical Structure Morphogenesis Canonical Wnt Signaling Pathway Neuron Differentiation Signaling Tissue Morphogenesis Regulation Of Embryonic Development Cell Communication Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway System Development Regulation Of Signaling Nervous System Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Wnt Signaling Pathway Generation Of Neurons Receptor Clustering Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurogenesis Nucleotide Phosphorylation Organ Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Hard Palate Development Signal Transduction Morphogenesis Of A Branching Epithelium Epithelium Development Ureteric Bud Morphogenesis Negative Regulation Of Signal Transduction Morphogenesis Of A Branching Structure Developmental Process Negative Regulation Of Signaling Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of BMP Signaling Pathway Stem Cell Proliferation Positive Regulation Of Signal Transduction Response To Stimulus Tube Development Cell Morphogenesis Involved In Differentiation Renal Tubule Development Cell Proliferation	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cell Fate Specification Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Fate Commitment Organ Morphogenesis Regulation Of Cell Fate Specification Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Muscle Cell Differentiation Regulation Of Cell Fate Commitment Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Epithelial Tube Morphogenesis Positive Regulation Of Receptor Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Tube Morphogenesis Positive Regulation Of MAPK Cascade Muscle Structure Development Regulation Of Cardiac Muscle Tissue Development Morphogenesis Of An Epithelium Cellular Response To Organic Substance Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Regulation Of Cellular Protein Metabolic Process Cellular Response To Retinoic Acid Skeletal System Development Wound Healing Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Embryonic Morphogenesis Stem Cell Proliferation Tissue Morphogenesis Canonical Wnt Signaling Pathway Renal Tubule Development Response To Wounding Tube Development Regulation Of Catalytic Activity Kidney Morphogenesis
Tagcloud ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms
Tagcloud (Difference) ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms
Tagcloud (Intersection) ?