WNT3A and GPC3

Number of citations of the paper that reports this interaction (PubMedID 16227623)
0

Data Source:
HPRD (in vivo)

		WNT3A	GPC3
Description		Wnt family member 3A	glypican 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Early Endosome Membrane Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Wnt-Frizzled-LRP5/6 Complex	Lysosome Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Side Of Membrane
	Molecular Function	Transcription Coactivator Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Co-receptor Binding Identical Protein Binding Receptor Ligand Activity	Protein Binding Peptidase Inhibitor Activity Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Heart Looping Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Determination Of Left/right Symmetry Axonogenesis Axon Guidance Mesoderm Development Heart Development Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification COP9 Signalosome Assembly Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Neurogenesis Hemopoiesis Platelet Activation Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Synaptic Vesicle Recycling B Cell Proliferation Inner Ear Morphogenesis Cell Fate Commitment Fat Cell Differentiation Myoblast Differentiation Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Division Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Animal Organ Development Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Canonical Wnt Signaling Pathway Cardiac Muscle Cell Fate Commitment Positive Regulation Of Dermatome Development Secondary Palate Development Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Presynapse Assembly Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Regulation Of Postsynapse To Nucleus Signaling Pathway Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Smoothened Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Bacterium Anatomical Structure Morphogenesis Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Signal Transduction Body Morphogenesis Cell Migration Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Regulation Of Growth Cell Migration Involved In Gastrulation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of D-glucose Import Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants Formation of paraxial mesoderm Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Alcohol-related hepatocellular carcinoma ( 34902334) Birth weight ( 31043758) Diastolic blood pressure ( 28135244) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401)	Educational attainment (years of education) ( 30038396) Relative hand skill ( 24068947)
Interacting Genes		11 interacting genes: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2	6 interacting genes: APPL1 FGF2 IGF2 PTPRS WNT3A WNT7B
Entrez ID		89780	2719
HPRD ID		05897	02074
Ensembl ID		ENSG00000154342	ENSG00000147257
Uniprot IDs		P56704	B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs		7DRT 7URD 7URE 8TZR	7ZA1 7ZAW
Enriched GO Terms of Interacting Partners?		Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Wnt Signaling Pathway Wnt-protein Binding Central Nervous System Neuron Differentiation Cell-cell Signaling Signaling Cell Communication Wnt Signalosome Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Wnt Receptor Activity Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Cellular Component Organization Neuron Differentiation Branching Involved In Ureteric Bud Morphogenesis Glial Cell-neuron Signaling Tissue Morphogenesis Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Signal Transduction Hard Palate Development GMP Kinase Activity Endocytic Vesicle Membrane Neuromuscular Junction Protein Localization To Cell Junction GDP Metabolic Process Juxtaparanode Region Of Axon Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tube Morphogenesis Protein Localization To Membrane Chemical Synaptic Transmission Kinase Binding Cellular Response To Potassium Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Developmental Process Trans-synaptic Signaling Regulation Of BMP Signaling Pathway Neurogenesis	Positive Regulation Of Cell Fate Specification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Embryonic Placenta Morphogenesis Regulation Of Developmental Growth Canonical Wnt Signaling Pathway Embryonic Morphogenesis Osteoblast Differentiation Positive Regulation Of Cell Fate Commitment Receptor Ligand Activity Regulation Of Growth Positive Regulation Of Developmental Growth Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Collateral Sprouting Regulation Of Cell Fate Specification Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Regulation Of Skeletal Muscle Tissue Development Regulation Of Cell Differentiation Cytokine Activity Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Growth Chordate Embryonic Development In Utero Embryonic Development Synapse Organization Frizzled Binding Regulation Of Cell Communication Regulation Of Signaling Wnt Signaling Pathway Regulation Of Fibroblast Migration Regulation Of Striated Muscle Tissue Development Cell Development Positive Chemotaxis Regulation Of Muscle Organ Development Regulation Of Cell Fate Commitment Cell Surface Receptor Signaling Pathway Positive Regulation Of Organ Growth Non-canonical Wnt Signaling Pathway Negative Regulation Of Axonogenesis Positive Regulation Of Neural Precursor Cell Proliferation Neuron Differentiation Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Retinoic Acid Signal Transduction Tissue Morphogenesis Hippocampus Development
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