NAT2 and HMMR

Number of citations: 0 (PubMedID 25640309)
Data Source: BioGRID (two hybrid)

		NAT2	HMMR
Name		N-acetyltransferase 2	hyaluronan mediated motility receptor
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane
	Molecular Function	Arylamine N-acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity N-hydroxyarylamine O-acetyltransferase Activity	Protein Binding Hyaluronic Acid Binding Cargo Receptor Activity
	Biological Process	Xenobiotic Metabolic Process	Receptor-mediated Endocytosis Hyaluronan Catabolic Process
Pathways		Acetylation Paracetamol ADME	Hyaluronan metabolism Hyaluronan degradation AURKA Activation by TPX2
Drugs		None	Hyaluronic acid
GWAS		Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Bladder cancer ( 20972438 24163127 ) Cholesterol, total ( 20686565 24097068 ) Coronary artery disease ( 29212778 33020668 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Insulin resistance/response ( 25798622 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Iron status biomarkers (transferrin levels) ( 25352340 ) LDL cholesterol levels ( 32203549 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Liver injury in anti-tuberculosis drug treatment ( 31109976 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 31589552 ) Metabolic traits ( 21886157 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Paclitaxel-induced neuropathy ( 23776197 ) Serum metabolite levels ( 33031748 ) Total cholesterol levels ( 28334899 33339817 ) Triglyceride levels ( 29403010 32203549 33339817 30698716 28334899 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 20686565 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites ( 26352407 21572414 ) Urinary metabolites (H-NMR features) ( 24586186 ) Youthful appearance (self-reported) ( 32339537 )	Metabolite levels ( 23823483 )
Interacting Genes		17 interacting genes: APC APP AURKA BAG4 CDKN2A CDKN2C ERBB2 FZR1 HMMR IGF1R MBD4 NAA10 NBN PALB2 PPM1D STK11 WT1	18 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 CEBPA CFTR GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A
Entrez ID		10	3161
HPRD ID		02000	02963
Ensembl ID		ENSG00000156006	ENSG00000072571
Uniprot IDs		A4Z6T7 A9X7Q9 P11245	O75330
PDB IDs		2PFR	Not available
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Component Organization DNA Damage Response Response To Stress Nucleus Regulation Of Protein Metabolic Process Cytosol Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Modification Process Positive Regulation Of Catabolic Process Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Apoptotic Process Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Growth Negative Regulation Of Cell Cycle Negative Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Metabolic Process Developmental Growth Regulation Of Proteolysis Protein Localization To Organelle Regulation Of Reproductive Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Cell Growth Positive Regulation Of Proteolysis Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Growth Negative Regulation Of Chromosome Organization Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity	Focal Adhesion Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Calyx Of Held