NAT2

Gene Name		N-acetyltransferase 2 (arylamine N-acetyltransferase)
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Arylamine N-acetyltransferase Activity
	Biological Process	Xenobiotic Metabolic Process Small Molecule Metabolic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Acetylation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Cholesterol, total ( 20686565) Metabolic traits ( 21886157) Paclitaxel-induced neuropathy ( 23776197) Triglycerides ( 20686565) Urinary metabolites ( 21572414)
Protein-protein Interactions		2 interactors: APP NAA10
Entrez ID		10
HPRD ID		02000
Ensembl ID		ENSG00000156006
Uniprot IDs		A4Z6T7 P11245
PDB IDs		2PFR
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction N-terminal Peptidyl-glutamic Acid Acetylation N-terminal Peptidyl-serine Acetylation Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling N-terminal Protein Amino Acid Acetylation Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle N-terminal Protein Amino Acid Modification Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process
Tagcloud ?		accounting acetylators acetyltransferase amines aromatic carcinogenic cigarette cigarettes detoxify distant explain exposures heterogeneity incident inconsistent intervals making neither past polymorphisms postmenopausal premenopausal quartile slow smoke smoked smoking susceptible whites