NAT2 and NAA10

Number of citations of the paper that reports this interaction (PMID 12888564)
17

Data Source:
HPRD (in vitro)

		NAT2	NAA10
Gene Name		N-acetyltransferase 2 (arylamine N-acetyltransferase)	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Intracellular Nucleus Nucleolus Cytoplasm Membrane Cytosolic Ribosome NatA Complex
	Molecular Function	Arylamine N-acetyltransferase Activity	Peptide Alpha-N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Acetyltransferase Activity Ribosome Binding Peptide-serine-N-acetyltransferase Activity Peptide-glutamate-N-acetyltransferase Activity
	Biological Process	Xenobiotic Metabolic Process Small Molecule Metabolic Process	DNA Packaging N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation N-terminal Peptidyl-serine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Acetylation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Cholesterol, total ( 20686565) Metabolic traits ( 21886157) Paclitaxel-induced neuropathy ( 23776197) Triglycerides ( 20686565) Urinary metabolites ( 21572414)
Protein-Protein Interactions		2 interactors: APP NAA10	24 interactors: BCOR CALCOCO2 CDC25A CEP44 EHMT2 FIP1L1 HIF1A KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-7 MEOX2 NAA15 NAA16 NAA50 NAT1 NAT2 PDE4DIP PSME2 RAB3IP RBCK1 RPL26 SSX2IP ZBTB14
Entrez ID		10	8260
HPRD ID		02000	02056
Ensembl ID		ENSG00000156006
Uniprot IDs		A4Z6T7 P11245	B4DKJ7 B7Z9N2 P41227
PDB IDs		2PFR
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction N-terminal Peptidyl-glutamic Acid Acetylation N-terminal Peptidyl-serine Acetylation Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling N-terminal Protein Amino Acid Acetylation Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle N-terminal Protein Amino Acid Modification Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process	N-terminal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Modification Protein Acetylation Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Protein Stabilization Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Regulation Of Cell Death Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Cellular Protein Modification Process Neutral Amino Acid Transport Negative Regulation Of Histone H3-K36 Methylation Mitotic Sister Chromatid Cohesion, Centromeric Neural Fold Elevation Formation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Viral Process Cellular Protein Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Bone Mineralization Negative Regulation Of Tooth Mineralization Elastin Metabolic Process Protein Metabolic Process Negative Regulation Of Ossification Microtubule-based Movement Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Protein Linear Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development DNA Methylation On Cytosine Within A CG Sequence Intestinal Epithelial Cell Maturation Cellular Nitrogen Compound Metabolic Process Palate Development Positive Regulation Of Transcription, DNA-templated Histone Modification Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Specification Of Axis Polarity Norepinephrine Transport Amino Acid Transmembrane Transport Gene Expression Regulation Of Transcription, DNA-templated
Tagcloud ?		accounting acetylators acetyltransferase amines aromatic carcinogenic cigarette cigarettes detoxify distant explain exposures heterogeneity incident inconsistent intervals making neither past polymorphisms postmenopausal premenopausal quartile slow smoke smoked smoking susceptible whites	00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 predisposition predominance prototype prototypic prps2 replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Difference) ?		accounting acetylators acetyltransferase amines aromatic carcinogenic cigarette cigarettes detoxify distant explain exposures heterogeneity incident inconsistent intervals making neither past polymorphisms postmenopausal premenopausal quartile slow smoke smoked smoking susceptible whites	00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 predisposition predominance prototype prototypic prps2 replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Intersection) ?