SUPT20H and AQP2

Number of citations of the paper that reports this interaction (PubMedID 28931009)
46

Data Source:
BioGRID (two hybrid)

		SUPT20H	AQP2
Description		SPT20 homolog, SAGA complex component	aquaporin 2
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GO Annotations	Cellular Component	SAGA Complex Nucleus SAGA-type Complex	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Transcription Coregulator Activity Protein Binding	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity
	Biological Process	Regulation Of DNA Repair Regulation Of Transcription By RNA Polymerase II Autophagy Gastrulation Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		HATs acetylate histones	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Platelet distribution width ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		10 interacting genes: AQP2 ATXN1 AURKA H3-4 LCOR MAP3K7 MAPK1 MAPK14 STAT3 UBQLN4	60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		55578	359
HPRD ID		10135	00141
Ensembl ID		ENSG00000102710	ENSG00000167580
Uniprot IDs		A8K8L1 Q8NEM7 R4GND2	P41181
PDB IDs		7KTR 7KTS 8H7G	4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Peptide Response To Cytokine Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Tumor Necrosis Factor Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Metabolic Process Protein Serine Kinase Activity Response To Tumor Necrosis Factor Phosphorylation Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway P38MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Astrocyte Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DNA-binding Transcription Factor Binding Insulin-like Growth Factor Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Erythrocyte Differentiation Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Biological Quality Carbohydrate Transmembrane Transport Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Nucleus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Locomotion Carbohydrate Transport Kinase Activity Regulation Of Erythrocyte Differentiation Canonical NF-kappaB Signal Transduction Nucleoplasm Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription By RNA Polymerase II Regulation Of Signal Transduction Response To Growth Factor	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport
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