UFSP1 and VAX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UFSP1	VAX2
Description		UFM1 specific peptidase 1	ventral anterior homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Cytoplasm
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeUFMylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Protein Maturation Protein Ufmylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ectoderm Development Axonogenesis Central Nervous System Development Brain Development Visual Perception Dorsal/ventral Axis Specification Wnt Signaling Pathway Neuron Differentiation Forebrain Development Camera-type Eye Development Embryonic Eye Morphogenesis Retina Development In Camera-type Eye
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 20639392 27798624 29769521)	Acne (severe) ( 24927181) Atopic dermatitis ( 26482879) Corneal astigmatism ( 23322567) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (functional units) ( 27694959) Serum metabolite levels ( 33031748)
Interacting Genes		43 interacting genes: C10orf55 CIDEB CIDEC COG6 CREB5 CSTF2 FAM222B FANCL FOXH1 FOXI1 GLYCTK GPSM3 HNF1B HOXC9 HSF4 INCA1 KRTAP15-1 LASP1 MSRB3 MYOZ3 PITX1 PITX2 POGZ POU6F2 PROP1 PRR22 RAPGEF3 RBM14 RBPMS2 RUSC1 SMARCC1 SNRPC SPG21 TBX3 TCF7L2 TLX3 UBQLN2 VAC14 VAX2 VGLL3 VPS37C WWOX ZIC1	3 interacting genes: PFDN5 POU6F2 UFSP1
Entrez ID		402682	25806
HPRD ID		18630	05051
Ensembl ID		ENSG00000176125	ENSG00000116035
Uniprot IDs		A0AAR1ZLH9 Q6NVU6	F1T0K5 Q9UIW0
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Chromatin Embryonic Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Animal Organ Morphogenesis Pattern Specification Process Hepatoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Myoblast Fate Commitment DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process System Development Transcription Regulator Complex Central Nervous System Development Somatotropin Secreting Cell Differentiation Regulation Of Primary Metabolic Process Embryonic Hindlimb Morphogenesis Regionalization Gland Development Pituitary Gland Development Lipid Droplet Fusion Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Hindlimb Morphogenesis Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Transcription Cis-regulatory Region Binding Inner Ear Morphogenesis Outflow Tract Morphogenesis Lipid Transfer Activity Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Axis Specification	RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly DeUFMylase Activity Prefoldin Complex Protein Ufmylation Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation
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