CCNC and MBP

Number of citations of the paper that reports this interaction (PMID 15328539)
1

Data Source:
BioGRID (enzymatic study)

		CCNC	MBP
Gene Name		cyclin C	myelin basic protein
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase II, Holoenzyme Mediator Complex	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin
	Molecular Function	Protein Binding Protein Kinase Binding	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid
Pathways		Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		32 interactors: CCNH CDK3 CDK8 CRX CTD DYDC1 ERCC3 ESR1 ESR2 FOXP2 GLYR1 GOLGA2 KRT13 KRT15 KRT31 LZTS2 MBIP MBP MCM2 MED8 MEOX2 MGST3 NEFL NMNAT1 PBXIP1 PNMA5 PUF60 RB1 TADA3 TP63 TRIM39 ZNF18	72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		892	4155
HPRD ID		00456	01158
Ensembl ID		ENSG00000112237	ENSG00000197971
Uniprot IDs		E5RFK5 P24863 Q7Z4L3	P02686
PDB IDs		3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L	1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Intracellular Estrogen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Female Genitalia Development Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Prostate Gland Epithelium Morphogenesis Mitotic Cell Cycle Process Prostate Gland Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development G1/S Transition Of Mitotic Cell Cycle Genitalia Development Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Neuron Death Prostate Gland Development Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Vagina Development Uterus Development Negative Regulation Of Gene Expression Cell Cycle Chromosome Organization Chromatin Organization Cell Cycle Process Epithelial Cell Differentiation Involved In Prostate Gland Development Cell Death Death Nucleotide-excision Repair, DNA Damage Removal Regulation Of Gene Expression	Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process
Tagcloud ?		aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Difference) ?		aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Intersection) ?