PLEKHM1 and MUC2

Number of citations of the paper that reports this interaction (PubMedID 12820725)
0

Data Source:
HPRD (in vitro)

		PLEKHM1	MUC2
Description		pleckstrin homology and RUN domain containing M1	mucin 2, oligomeric mucus/gel-forming
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Cytoplasmic Vesicle Late Endosome Membrane Autolysosome Autolysosome Membrane	Extracellular Region Golgi Lumen Plasma Membrane Extracellular Matrix Inner Mucus Layer Outer Mucus Layer
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Cupric Ion Binding Cuprous Ion Binding
	Biological Process	Autophagy Protein Transport Lysosome Localization Positive Regulation Of Bone Resorption Autophagosome-lysosome Fusion Positive Regulation Of Ruffle Assembly Late Endosome To Lysosome Transport	Detoxification Of Copper Ion Maintenance Of Gastrointestinal Epithelium Host-mediated Modulation Of Intestinal Microbiota Composition Mucus Secretion
Pathways			Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs			Pranlukast Colforsin
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical volume ( 32963231) Daytime nap ( 33568662) Epithelial ovarian cancer ( 25581431) Hip circumference ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Male-pattern baldness ( 28196072 29146897) Monocyte count ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 20070850) Remission after SSRI treatment in MDD or neuroticism ( 29559929)	Asthma ( 30929738 31361310 31959851 32296059 34103634) Asthma (adult onset) ( 30929738) Interstitial lung disease ( 23583980) Medication use (adrenergics, inhalants) ( 31015401)
Interacting Genes		14 interacting genes: BID CTDSP1 EIF2S2 GADD45G MAP1LC3B MAPK1 MAPK6 MOB4 MTOR MUC2 PAFAH1B3 SERPINB9 TRIM54 VPS18	4 interacting genes: GALNT12 GALNT14 MLH1 PLEKHM1
Entrez ID		9842	4583
HPRD ID		11439	11828
Ensembl ID		ENSG00000225190	ENSG00000198788
Uniprot IDs		A0A8V8TPW0 Q9Y4G2	A0A3S8TMF2 Q02817
PDB IDs		5DPR 5DPS 5DPT 5DPW 8JC5	6RBF 6TM2 6TM6 7A5O 7POV 7PP6 7PRL 7QCL 7QCN 7QCU 8CK2 8S03
Enriched GO Terms of Interacting Partners?			Telomere Localization Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Organelle Localization Chromosome Localization Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Telomere Tethering At Nuclear Periphery Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protein O-linked Glycosylation Protein Glycosylation Glycosylation Macromolecule Glycosylation Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Pore Cytoplasmic Filaments Carbohydrate Binding Glycosyltransferase Activity Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Glycoprotein Biosynthetic Process Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Autolysosome Membrane Glycoprotein Metabolic Process Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Spindle Midzone Assembly Chromosome Organization Somatic Diversification Of Immune Receptors Via Somatic Mutation Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Nuclear Pore Nuclear Basket Nuclear Inclusion Body Nuclear Pore Organization Positive Regulation Of Ruffle Assembly Autolysosome Autophagosome-lysosome Fusion
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