PLEKHM1 and SERPINB9

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLEKHM1	SERPINB9
Gene Name		pleckstrin homology domain containing, family M (with RUN domain) member 1	serpin peptidase inhibitor, clade B (ovalbumin), member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Extracellular Space Nucleus Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Metal Ion Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Intracellular Signal Transduction	Mast Cell Mediated Immunity Immune Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Estrogen Stimulus
Pathways
Drugs
Diseases
GWAS		Parkinson's disease ( 20070850)
Protein-Protein Interactions		8 interactors: BID EIF2S2 GADD45G MAPK6 MOB4 MUC2 PAFAH1B3 SERPINB9	27 interactors: BRD7 C14orf1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1
Entrez ID		9842	5272
HPRD ID		11439	03480
Ensembl ID		ENSG00000225190	ENSG00000170542
Uniprot IDs		Q9Y4G2	P50453
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To X-ray Negative Regulation Of Fibroblast Proliferation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Response To Salt Stress Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Neuron Apoptotic Process Cellular Response To Ionizing Radiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitochondrion Organization Metabolic Process Regulation Of RNA Metabolic Process Neuron Death Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth Oligodendrocyte Apoptotic Process Apoptotic Process Positive Regulation Of Histone Modification Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cellular Process Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Hyperosmotic Salinity Response Cell Death Death Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Response To Osmotic Stress
Tagcloud ?		ablated c1 cathepsin colocalizes ctx declined depleted disorganized dynein hydrolase lis1 lysosomal lysosome master microtubule microtubules nfat organization osteoclast osteoclasts pits polykaryons rankl resorption secretion shrna specialized unrecognized virtue	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 cyb5a endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Difference) ?		ablated c1 cathepsin colocalizes ctx declined depleted disorganized dynein hydrolase lis1 lysosomal lysosome master microtubule microtubules nfat organization osteoclast osteoclasts pits polykaryons rankl resorption secretion shrna specialized unrecognized virtue	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 cyb5a endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Intersection) ?