PLEKHM1

Description		pleckstrin homology and RUN domain containing M1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Cytoplasmic Vesicle Late Endosome Membrane Autolysosome Autolysosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Autophagy Protein Transport Lysosome Localization Positive Regulation Of Bone Resorption Autophagosome-lysosome Fusion Positive Regulation Of Ruffle Assembly Late Endosome To Lysosome Transport
Pathways
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical volume ( 32963231) Daytime nap ( 33568662) Epithelial ovarian cancer ( 25581431) Hip circumference ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Male-pattern baldness ( 28196072 29146897) Monocyte count ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 20070850) Remission after SSRI treatment in MDD or neuroticism ( 29559929)
Interacting Genes		14 interacting genes: BID CTDSP1 EIF2S2 GADD45G MAP1LC3B MAPK1 MAPK6 MOB4 MTOR MUC2 PAFAH1B3 SERPINB9 TRIM54 VPS18
Entrez ID		9842
HPRD ID		11439
Ensembl ID		ENSG00000225190
Uniprot IDs		A0A8V8TPW0 Q9Y4G2
PDB IDs		5DPR 5DPS 5DPT 5DPW 8JC5
Enriched GO Terms of Interacting Partners?
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