EIF2B1 and EIF2B5

Number of citations of the paper that reports this interaction (PMID 17353931)
246

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EIF2B1	EIF2B5
Gene Name		eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Enzyme Regulator Activity S-methyl-5-thioribose-1-phosphate Isomerase Activity	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Ovarian Follicle Development Translation Translational Initiation Response To Heat Response To Glucose Gene Expression Astrocyte Development Oligodendrocyte Development Negative Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Cellular Response To Drug Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Astrocyte Differentiation
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		14 interactors: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D CREBBP EIF2B2 EIF2B5 EIF2S1 EIF2S2 GORASP2 MRPL4 RD3 WDYHV1	11 interactors: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 EIF2B1 EIF2B2 EIF2B4 EIF2S2 GSK3A GSK3B
Entrez ID		1967	8893
HPRD ID		09458	04898
Ensembl ID			ENSG00000145191
Uniprot IDs		Q14232	Q13144
PDB IDs		3ECS	3JUI
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Receptor Transactivation Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Regulation Of Smooth Muscle Contraction Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Norepinephrine Secretion Negative Regulation Of Smooth Muscle Contraction Translational Initiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Negative Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase B Activity Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Muscle Contraction Positive Regulation Of Receptor Activity Response To Temperature Stimulus Regulation Of Vasoconstriction Positive Regulation Of Protein Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Translational Initiation Positive Regulation Of Catalytic Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Translational Initiation In Response To Stress Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Translation Regulation Of Translation In Response To Stress Response To Heat Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Reproductive Process Regulation Of Kinase Activity Activation Of MAPK Activity Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Secretion By Cell	Wnt Signaling Pathway Response To Heat Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Oligodendrocyte Development Nervous System Development Hypermethylation Of CpG Island Negative Regulation Of Protein Metabolic Process Response To Temperature Stimulus Cellular Response To Interleukin-3 Neurogenesis Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hydrolase Activity Translational Initiation Negative Regulation Of Glycogen (starch) Synthase Activity Cell Development Protein Metabolic Process Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translation In Response To Stress Oligodendrocyte Differentiation System Development Regulation Of Wnt Signaling Pathway Rhythmic Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cellular Metabolic Process Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Glial Cell Development Multicellular Organismal Development Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Mitotic Nuclear Division Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Translation In Response To Stress Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Anatomical Structure Development Regulation Of Mitotic Cell Cycle Response To Glucose Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Translational Initiation
Tagcloud ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm