SLC5A6 and CHRM5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SLC5A6	CHRM5
Description		solute carrier family 5 member 6	cholinergic receptor muscarinic 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Sodium-dependent Multivitamin Transmembrane Transporter Activity Monoatomic Ion Transmembrane Transporter Activity Iodide Transmembrane Transporter Activity Biotin Transmembrane Transporter Activity Pantothenate Transmembrane Transporter Activity Symporter Activity Pantothenate:sodium Symporter Activity Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Vitamin Transmembrane Transporter Activity Monocarboxylate:sodium Symporter Activity Sulfur Compound Transmembrane Transporter Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Biotin Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Biotin Transport Pantothenate Transmembrane Transport Transmembrane Transport Inorganic Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Transport Across Blood-brain Barrier Iodide Transmembrane Transport Biotin Import Across Plasma Membrane	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway
Pathways		Biotin transport and metabolism Vitamin B5 (pantothenate) metabolism Transport of vitamins, nucleosides, and related molecules	Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs		Lipoic acid	Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Fasting blood glucose adjusted for BMI ( 25625282) Serum metabolite levels ( 33031748)	Malaria ( 31844061)
Interacting Genes		4 interacting genes: CHRM5 ERBIN GALNT6 UBC	31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33
Entrez ID		8884	1133
HPRD ID		04934	00331
Ensembl ID		ENSG00000138074	ENSG00000184984
Uniprot IDs		Q9HD19 Q9Y289	P08912 Q8IVW0
PDB IDs			6OL9
Enriched GO Terms of Interacting Partners?		G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Hemidesmosome ErbB-2 Class Receptor Binding Basal Protein Localization Negative Regulation Of Monocyte Chemotactic Protein-1 Production Postsynaptic Specialization	Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization
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