CDC16 and FBXO5

Number of citations of the paper that reports this interaction (PMID 16921029)
58

Data Source:
BioGRID (pull down)

		CDC16	FBXO5
Gene Name		cell division cycle 16	F-box protein 5
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Spindle Assembly Involved In Female Meiosis I Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Vesicle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Meiotic Nuclear Division Microtubule Polymerization Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Inhibition Of APC-Cdc20 Complex Activity
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	E2F mediated regulation of DNA replication G1/S Transition G1/S-Specific Transcription SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Mitotic Metaphase/Anaphase Transition Phosphorylation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Mitotic G1-G1/S phases M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		22 interactors: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC26 CDC27 CDH1 DAB2 DNAJA1 FBXO5 FTH1 HINT1 MAD2L1 PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5	16 interactors: ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BTRC CDC16 CDC20 CDC23 CDC27 CDK1 EVI5 FZR1 SKP1 TPM3
Entrez ID		8881	26271
HPRD ID		04587	09348
Ensembl ID		ENSG00000130177	ENSG00000112029
Uniprot IDs		Q13042	Q9UKT4
PDB IDs		3HYM	2M6N
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Mitotic Spindle Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Protein K11-linked Ubiquitination Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Cell Cycle Process Cell Division Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Spindle Assembly Checkpoint Positive Regulation Of Proteolysis Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Cell Cycle Checkpoint Regulation Of Chromosome Segregation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Checkpoint Protein Catabolic Process Protein Polyubiquitination Cell Division Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Protein Catabolic Process
Tagcloud ?		2a akt anabolic bub2 coimmunoprecipitated constant dephosphorylation homolog mechanistic modulator mtorc1 nutrients phosphorylates pp2a rapamycin redd1 repress represses repressor rheb ser stimulating tbc1d7 thr tre2 tsc tsc1 tsc2 tuberous
Tagcloud (Difference) ?		2a akt anabolic bub2 coimmunoprecipitated constant dephosphorylation homolog mechanistic modulator mtorc1 nutrients phosphorylates pp2a rapamycin redd1 repress represses repressor rheb ser stimulating tbc1d7 thr tre2 tsc tsc1 tsc2 tuberous
Tagcloud (Intersection) ?