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FBXO5 and BTRC
Number of citations of the paper that reports this interaction (PMID
15469984
)
63
Data Source:
BioGRID
(pull down)
FBXO5
BTRC
Gene Name
F-box protein 5
beta-transducin repeat containing E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Spindle
Cytosol
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Protein Kinase Binding
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Ligase Activity
Protein Phosphorylated Amino Acid Binding
Protein Dimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Oocyte Maturation
Spindle Assembly Involved In Female Meiosis I
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Vesicle Organization
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Meiotic Nuclear Division
Microtubule Polymerization
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Inhibition Of APC-Cdc20 Complex Activity
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Protein Dephosphorylation
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Circadian Rhythm
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Mammary Gland Epithelial Cell Proliferation
Regulation Of Circadian Rhythm
Positive Regulation Of Circadian Rhythm
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Proteolysis
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Cell Cycle
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Cellular Response To Organic Cyclic Compound
Pathways
E2F mediated regulation of DNA replication
G1/S Transition
G1/S-Specific Transcription
SCF-beta-TrCP mediated degradation of Emi1
Regulation of mitotic cell cycle
Mitotic Metaphase/Anaphase Transition
Phosphorylation of Emi1
Regulation of APC/C activators between G1/S and early anaphase
Mitotic G1-G1/S phases
M Phase
Mitotic Metaphase and Anaphase
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
Signaling by the B Cell Receptor (BCR)
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
Regulation of PLK1 Activity at G2/M Transition
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
RNF mutants show enhanced WNT signaling and proliferation
Prolactin receptor signaling
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Host Interactions of HIV factors
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Regulation of APC/C activators between G1/S and early anaphase
Signaling by ERBB4
APC/C-mediated degradation of cell cycle proteins
Signaling by Interleukins
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
Interleukin-1 signaling
Mitotic G2-G2/M phases
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
APC truncation mutants have impaired AXIN binding
HIV Infection
G2/M Transition
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
Class I MHC mediated antigen processing & presentation
Vpu mediated degradation of CD4
Cytokine Signaling in Immune system
Cell Cycle, Mitotic
Nuclear signaling by ERBB4
TCF dependent signaling in response to WNT
Activation of NF-kappaB in B cells
SCF-beta-TrCP mediated degradation of Emi1
Regulation of mitotic cell cycle
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
16 interactors:
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
BTRC
CDC16
CDC20
CDC23
CDC27
CDK1
EVI5
FZR1
SKP1
TPM3
72 interactors:
AGO2
AMER1
ATF4
AXIN1
BHLHE40
BORA
CCND1
CCNE1
CDC25A
CDC34
CDK1
CHPF
CHUK
CP
CTNNB1
CUL1
DBN1
DEPTOR
DLGAP5
E2F1
FBXO5
FBXW11
FOXO3
GH1
GHR
GLI3
GSK3B
HIPK2
HNRNPC
HNRNPK
HNRNPU
ICE1
JUP
KDR
MDM2
MYB
MYC
NFE2
NFKB1
NFKB2
NFKBIA
NFKBIB
PCDH8
PDCD4
PRDX1
PSMA3
PSMD4
RASSF5
RCAN1
RELA
SKP1
SMAD3
SMAD4
SMURF2
SP1
SUFU
TACC1
TAZ
TFAP4
TIAM1
TP63
TRIM9
TSPAN15
UBE2D2
UBE2D3
UBE2R2
UBQLN2
UHRF1
USP37
WEE1
YAP1
ZC3H12A
Entrez ID
26271
8945
HPRD ID
09348
04596
Ensembl ID
ENSG00000112029
ENSG00000166167
Uniprot IDs
Q9UKT4
B2R8L3
B7Z3H4
Q68DS0
Q9Y297
PDB IDs
2M6N
1P22
2P64
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Protein K11-linked Ubiquitination
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Ubiquitin-protein Transferase Activity
Spindle Assembly Checkpoint
Positive Regulation Of Proteolysis
Mitotic Spindle Checkpoint
Negative Regulation Of Chromosome Segregation
Spindle Checkpoint
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Negative Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Cell Division
Cell Cycle Checkpoint
Regulation Of Chromosome Segregation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Positive Regulation Of Transferase Activity
Negative Regulation Of Chromosome Organization
Mitotic Cell Cycle Checkpoint
Protein Catabolic Process
Protein Polyubiquitination
Cell Division
Regulation Of Proteolysis
Mitotic Cell Cycle Process
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Nuclear Division
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Response To Growth Factor
Cell Communication
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Cellular Metabolic Process
Regulation Of Signal Transduction
Signaling
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Cellular Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Transcription, DNA-templated
Intracellular Signal Transduction
Response To Organic Substance
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Apoptotic Process
Regulation Of Signaling
Programmed Cell Death
Regulation Of Transcription, DNA-templated
Cell Death
Death
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Signal Transduction
Cellular Response To Stimulus
Cell Cycle Process
Regulation Of Wnt Signaling Pathway
Regulation Of Protein Localization To Nucleus
Tagcloud
?
aggregate
austere
bias
biases
chamber
clinics
error
homes
humidity
individually
instruments
isolate
meter
meters
minutes
poc
rank
reagent
responders
signed
spiked
static
stressed
stresses
strip
strips
tenney
unstressed
wilcoxon
Tagcloud (Difference)
?
aggregate
austere
bias
biases
chamber
clinics
error
homes
humidity
individually
instruments
isolate
meter
meters
minutes
poc
rank
reagent
responders
signed
spiked
static
stressed
stresses
strip
strips
tenney
unstressed
wilcoxon
Tagcloud (Intersection)
?