TUBB3 and PHIP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TUBB3	PHIP
Description		tubulin beta 3 class III	PHIP subunit of CUL4-Ring ligase complex
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Lamellipodium Filopodium Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Intercellular Bridge Extracellular Exosome Cell Periphery Mitotic Spindle	Nucleus
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding Metal Ion Binding Netrin Receptor Binding	Insulin Receptor Binding Protein Binding Histone Reader Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Axon Guidance Neuron Differentiation Netrin-activated Signaling Pathway Dorsal Root Ganglion Development	Regulation Of Protein Phosphorylation Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Shape Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	RHOBTB2 GTPase cycle
Drugs		Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases		Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)	Diastolic blood pressure ( 27618448 27841878) Intelligence (MTAG) ( 29326435) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Mean arterial pressure ( 27618448) Sjögren's syndrome ( 24097067) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		38 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH OGT PHIP PLK1 RCC1 RILPL2 ROBO1 RSPH1 SCGN SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE WEE2-AS1	3 interacting genes: IRS1 STMN4 TUBB3
Entrez ID		10381	55023
HPRD ID		04044	10152
Ensembl ID		ENSG00000258947	ENSG00000146247
Uniprot IDs		Q13509 Q53G92	A0A8V8TPV5 Q8WWQ0
PDB IDs		5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 8VRJ 8VRK 8VT7	3MB3 5ENB 5ENC 5ENE 5ENF 5ENH 5ENI 5ENJ 5RJI 5RJJ 5RJK 5RJL 5RJM 5RJN 5RJO 5RJP 5RJQ 5RJR 5RJS 5RJT 5RJU 5RJV 5RJW 5RJX 5RJY 5RJZ 5RK0 5RK1 5RK2 5RK3 5RK4 5RK5 5RK6 5RK7 5RK8 5RK9 5RKA 5RKB 5RKC 5RKD 5RKE 5RKF 5RKG 5RKH 5RKI 5RKJ 5RKK 5RKL 5RKM 5RKN 5RKO 5RKP 5RKQ 5RKR 5RKS 5RKT 5RKU 5RKV 5RKW 5RKX 5RKY 5S8C 5S8D 5S8E 5S8F 5S8G 5S8H 5S8I 5S8J 5S8K 5S8L 5S8M 5S8N 5S8O 5S8P 5S8Q 5S8R 5S8S 5S8T 5S8U 5S8V 5S8W 5S8X 5S8Y 5S8Z 5S90 5S91 5S92 5S93 5S94 5S95 5S96 5S97 5S98 5S99 5S9A 5S9B 5S9C 5S9D 5S9E 5S9G 5S9J 7AV8 7AV9 7BBO 7BBP 7FUS 7FUT 7FUU 7FUV 7FUW 7FUX 7FUY 7FUZ 7FV0 7FV1 7FV2 7FV3 7FV4 7FV5 7FV6 7FV7 7FV8 7FV9 7FVA 7FVB 7FVC 7FVD 7FVE 7FVF 7FVG 7FVH 7FVI 7FVJ 7FVK 7FVL 7FVM 7FVN 7FVO 7FVP 7FVQ 7FVR 8BW2 8BW3 8BW4 9GH3
Enriched GO Terms of Interacting Partners?		Microtubule Binding Regulation Of Protein-containing Complex Assembly Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Synapse Regulation Of Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Intercellular Canaliculus Regulation Of Protein K48-linked Ubiquitination Cytoskeleton Organization Microtubule-based Process Regulation Of Protein Modification Process Organelle Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Mitotic Nuclear Division Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Regulation Of Microtubule-based Process Cellular Component Assembly Mitotic Cell Cycle Phase Transition	Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Insulin Receptor Complex Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Binding Positive Regulation Of Fatty Acid Oxidation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Netrin-activated Signaling Pathway Axon Netrin Receptor Binding Ganglion Development Dorsal Root Ganglion Development Microtubule Cytoskeleton Organization Neuron Projection Development Growth Cone Microtubule Depolymerization Negative Regulation Of Insulin Secretion Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Cellular Response To Insulin Stimulus SH2 Domain Binding Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Fatty Acid Positive Regulation Of Lipid Catabolic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Peptide Secretion Positive Regulation Of D-glucose Import Protein Kinase C Binding Regulation Of Fatty Acid Oxidation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Insulin Receptor Binding Regulation Of Glycogen Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Plasma Membrane Bounded Cell Projection Organization Peptide Binding Microtubule-based Process Microtubule Polymerization Or Depolymerization Protein Depolymerization Cytoskeleton Organization Response To Fatty Acid Regulation Of Lipid Catabolic Process Regulation Of D-glucose Import Tubulin Binding Cell Projection Organization Negative Regulation Of Hormone Secretion
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