TUBB3 and RILPL2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TUBB3	RILPL2
Description		tubulin beta 3 class III	Rab interacting lysosomal protein like 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Lamellipodium Filopodium Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Intercellular Bridge Extracellular Exosome Cell Periphery Mitotic Spindle	Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding Metal Ion Binding Netrin Receptor Binding	Protein Binding Small GTPase Binding Identical Protein Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Axon Guidance Neuron Differentiation Netrin-activated Signaling Pathway Dorsal Root Ganglion Development	Epithelial Cell Morphogenesis Protein Transport Cilium Assembly Protein Transport From Ciliary Membrane To Plasma Membrane
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases		Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Educational attainment ( 25201988) Height ( 28552196) High density lipoprotein cholesterol levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252) Schizophrenia ( 25056061 29483656 23974872) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		38 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH OGT PHIP PLK1 RCC1 RILPL2 ROBO1 RSPH1 SCGN SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE WEE2-AS1	2 interacting genes: HEXD TUBB3
Entrez ID		10381	196383
HPRD ID		04044	10084
Ensembl ID		ENSG00000258947	ENSG00000150977
Uniprot IDs		Q13509 Q53G92	Q969X0
PDB IDs		5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 8VRJ 8VRK 8VT7	6RIR 6SQ2 7LWB
Enriched GO Terms of Interacting Partners?		Microtubule Binding Regulation Of Protein-containing Complex Assembly Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Synapse Regulation Of Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Intercellular Canaliculus Regulation Of Protein K48-linked Ubiquitination Cytoskeleton Organization Microtubule-based Process Regulation Of Protein Modification Process Organelle Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Mitotic Nuclear Division Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Regulation Of Microtubule-based Process Cellular Component Assembly Mitotic Cell Cycle Phase Transition	Netrin Receptor Binding Dorsal Root Ganglion Development Beta-N-acetylhexosaminidase Activity Hexosaminidase Activity Microtubule Netrin-activated Signaling Pathway Ganglion Development Minus-end-directed Microtubule Motor Activity Axonemal Dynein Complex Peptide Binding Microtubule-based Process 9+2 Motile Cilium Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Dynein Complex Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Microtubule Motor Activity
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