TUBB3 and MRPL28

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TUBB3	MRPL28
Gene Name		tubulin, beta 3 class III	mitochondrial ribosomal protein L28
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Axon Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Cell Periphery	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding	Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Folding Microtubule-based Process Mitotic Nuclear Division Axon Guidance Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Transmembrane Transport	Translation Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System	Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination
Drugs		Epothilone D Epothilone B Ixabepilone
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ANXA7 ARHGEF7 CAMSAP3 CDKN1A DDX39B EEF1G GABARAP GZMK HEXDC INSM1 KHDRBS1 LAPTM4A LIG1 MRPL28 MTCL1 PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE	12 interactors: APP BANP CDR2 FAM9B HMBOX1 HTR2A IKZF3 OXA1L TEF TRAF3IP2 TRAF4 TUBB3
Entrez ID		10381	10573
HPRD ID		04044	06889
Ensembl ID		ENSG00000258947	ENSG00000086504
Uniprot IDs		A8K854 Q13509 Q53G92	Q13084
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Mitotic Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Division Cell Cycle Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Response To Toxic Substance Negative Regulation Of Chromosome Segregation Cell Division Cytoskeleton Organization Microtubule Bundle Formation Positive Regulation Of Microtubule Motor Activity Fetal Process Involved In Parturition Columnar/cuboidal Epithelial Cell Development Regulation Of DNA Biosynthetic Process Microtubule-based Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Epithelial Cell Development Regulation Of Cell Morphogenesis Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Spliceosomal Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Cell Death Death Phospholipase C-activating Serotonin Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Mitochondrial Proton-transporting ATP Synthase Complex Assembly Collateral Sprouting In Absence Of Injury Proton-transporting ATP Synthase Complex Assembly Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Protein Binding Cellular Localization Collateral Sprouting Axon Midline Choice Point Recognition Adult Behavior Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Immunoglobulin Secretion Positive Regulation Of Phospholipid Biosynthetic Process Axon Choice Point Recognition Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Biosynthetic Process Artery Smooth Muscle Contraction Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of ATPase Activity Tonic Smooth Muscle Contraction B Cell Apoptotic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Neuron Remodeling Positive Regulation Of Protein Homodimerization Activity Urinary Bladder Smooth Muscle Contraction Regulation Of Binding Learning Or Memory Positive Regulation Of Glycolytic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Protein Localization Serotonin Receptor Signaling Pathway Vascular Smooth Muscle Contraction Behavioral Response To Cocaine RNA Metabolic Process Cognition Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Respiratory Chain Complex I Biogenesis Negative Regulation Of Synaptic Transmission, Glutamatergic Apoptotic Process Cellular Calcium Ion Homeostasis Sleep Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Calcium Ion Homeostasis Programmed Cell Death
Tagcloud ?		actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2	asexual candida cerevisiae chromosome cluster coding contains else equivalent exclude fourth gcn3 glabrata his3 homologues includes kb mating mfa1 pathogenic rearrangement saccharomyces section sequenced somewhere stp1 tfb3 xi xv
Tagcloud (Difference) ?		actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2	asexual candida cerevisiae chromosome cluster coding contains else equivalent exclude fourth gcn3 glabrata his3 homologues includes kb mating mfa1 pathogenic rearrangement saccharomyces section sequenced somewhere stp1 tfb3 xi xv
Tagcloud (Intersection) ?