TSC22D1 and DNASE1

		TSC22D1	DNASE1
Description		TSC22 domain family member 1	deoxyribonuclease 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Extracellular Region Nucleus Nuclear Envelope Cytoplasmic Vesicle Zymogen Granule Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	DNA Binding Actin Binding Catalytic Activity Nuclease Activity Endonuclease Activity Deoxyribonuclease I Activity DNA Nuclease Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation	Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Catabolic Process Apoptotic Process Regulation Of Neutrophil Mediated Cytotoxicity
Pathways
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)	Body mass index ( 29273807) Monocyte percentage of white cells ( 32888494)
Interacting Genes		51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1	4 interacting genes: ACTA1 ACTA2 ACTB ACTG1
Entrez ID		8848	1773
HPRD ID		07414	00509
Ensembl ID		ENSG00000102804	ENSG00000213918
Uniprot IDs		A8K3Y6 Q15714	P24855
PDB IDs			4AWN
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Actin Cytoskeleton Mesenchyme Migration Regulation Of Transepithelial Transport Dense Body Actin Filament Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Lamellipodium Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Positive Regulation Of Macromolecule Biosynthetic Process Platelet Aggregation Positive Regulation Of Biosynthetic Process Homotypic Cell-cell Adhesion Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Filopodium Cytoskeleton Cell Body Extracellular Space Stress Fiber Positive Regulation Of Hepatic Stellate Cell Contraction Protein Localization To Cell Junction Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Metabolic Process Schaffer Collateral - CA1 Synapse Hydrolase Activity Nucleotide Binding Cell-cell Junction Assembly Positive Regulation Of Hepatic Stellate Cell Migration Regulation Of Norepinephrine Uptake Axonogenesis Juxtaglomerular Apparatus Development Transporter Regulator Activity Extracellular Exosome Cell-cell Junction Organization Glomerular Mesangial Cell Development Smooth Muscle Contractile Fiber
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